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Lactobacillus plantarum CCFM639 Alleviate Trace Element Imbalance-Related Oxidative Stress in Liver and Kidney of Chronic Aluminum Exposure Mice

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Abstract

Aluminum (Al) has various adverse effects on health of humans and animals. The aim of present study was to demonstrate that Lactobacillus plantarum CCFM639 can alleviate the adverse effects on liver and kidney of mice caused by chronic Al exposure. Animals were assigned into control, CCFM639 only, Al only, Al plus CCFM639, and Al plus deferiprone groups. The strain was given by oral gavage for 14 weeks, and Al was introduced via drinking water for the first 8 weeks. Analyses of Al and trace elements levels in feces, blood, and tissues were performed. The biochemical markers (GSH, GPx, SOD, CAT, and MDA) of oxidative stress in livers and kidneys, as well as the levels of ALT, AST, BUN, and CRE in blood, were determined. Our results showed that L. plantarum CCFM639 can significantly reduce Al accumulation in tissues, regulate imbalance of trace elements, and thereby alleviate oxidative stress and pathological changes in hepatic and renal tissues. Therefore, L. plantarum CCFM639 could alleviate Al-induced hepatic and renal injuries, and the possible mechanisms may involve in regulating the imbalance of trace elements.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China Key Program (No. 31530056), the National Natural Science Foundation of China (Nos. 31470161 and 31371721), the National Natural Science Foundation of Jiangsu Province (BK20160175), BBSRC Newton Fund Joint Centre Award, the Self-Determined Research Program of Jiangnan University (JUSRP 115A23), and Grain Industry Research Special Funds for Public Welfare Projects (No. 201513006-03).

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Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, People’s Republic of China

    Leilei Yu, Qixiao Zhai, Ruijie Yin, Peng Li, Fengwei Tian, Xiaoming Liu, Jianxin Zhao, Jianhua Gong, Hao Zhang & Wei Chen

  2. UK-China Joint Centre on Probiotic Bacteria, Norwich, NR4 7UA, UK

    Leilei Yu, Qixiao Zhai, Fengwei Tian, Hao Zhang & Wei Chen

  3. Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, 100048, People’s Republic of China

    Wei Chen

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  1. Leilei Yu
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  2. Qixiao Zhai
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  3. Ruijie Yin
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  4. Peng Li
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  5. Fengwei Tian
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  8. Jianhua Gong
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  9. Hao Zhang
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  10. Wei Chen
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Correspondence to Fengwei Tian or Wei Chen.

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Leilei Yu and Qixiao Zhai contributed equally to this study.

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Yu, L., Zhai, Q., Yin, R. et al. Lactobacillus plantarum CCFM639 Alleviate Trace Element Imbalance-Related Oxidative Stress in Liver and Kidney of Chronic Aluminum Exposure Mice. Biol Trace Elem Res 176, 342–349 (2017). https://doi.org/10.1007/s12011-016-0843-8

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