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Magnesium Status and Its Relationship with C-Reactive Protein in Obese Women

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Abstract

This study assessed the relationship between magnesium status and C-reactive protein concentration in obese and nonobese women. This cross-sectional study included 131 women, aged between 20 and 50 years, who were divided into two groups: obese (n = 65) and control (n = 66) groups. Magnesium intake was monitored using 3-day food records and NutWin software version 1.5. The plasma, erythrocyte, and urinary magnesium concentrations were determined by flame atomic absorption spectrophotometry. C-reactive protein concentration in serum was measured by immunoturbidimetric assay. The mean values of the magnesium content in the diet were lower than those recommended, though there was no significant difference between groups (p > 0.05). The mean concentrations of plasma and erythrocyte magnesium were within the normal range, with no significant difference between groups (p > 0.05). Urinary excretion of this mineral was less than the reference values in both groups, with no significant difference (p > 0.05). The mean concentration of serum C-reactive protein was within the normal range in both groups, with no significant difference (p > 0.05). There was a positive correlation between urinary magnesium and serum C-reactive protein (p = 0.015). Obese patients ingest low dietary magnesium content, which seems to induce hypomagnesuria as a compensatory mechanism to keep plasma concentrations of the mineral at adequate levels. The study shows a positive correlation between urinary magnesium concentrations and serum C-reactive protein, suggesting the influence of hypomagnesuria on this inflammatory protein in obese women.

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Conflict of Interest

The authors declare that they have no competing interest.

Ethical Standards

This study was approved by the Research Ethics Committee of the Federal University of Piauí (protocol number 27565414.4.0000.5214) and conducted in accordance with the Declaration of Helsinki. All participants gave their full consent.

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Authors and Affiliations

  1. Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil

    Ana Raquel Soares de Oliveira, Kyria Jayanne Clímaco Cruz, Jennifer Beatriz Silva Morais, Juliana Soares Severo, Taynáh Emannuelle Coelho de Freitas, Nadir do Nascimento Nogueira & Dilina do Nascimento Marreiro

  2. Clinical Pathology Laboratory Antonio Lobão, Teresina, Piauí, Brazil

    Antonio Lobão Veras

  3. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Butantã, São Paulo, São Paulo, Brazil

    Amanda Batista da Rocha Romero & Célia Colli

  4. Department of Physiology and Biophysics, Federal University of Piauí, Campus Minister Petrônio Portela, Ininga, Teresina, Piauí, Brazil

    Francisco Leonardo Torres-Leal

Authors
  1. Ana Raquel Soares de Oliveira
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  2. Kyria Jayanne Clímaco Cruz
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  3. Jennifer Beatriz Silva Morais
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  4. Juliana Soares Severo
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  5. Taynáh Emannuelle Coelho de Freitas
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  6. Antonio Lobão Veras
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  7. Amanda Batista da Rocha Romero
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  8. Célia Colli
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  9. Nadir do Nascimento Nogueira
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  10. Francisco Leonardo Torres-Leal
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  11. Dilina do Nascimento Marreiro
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Corresponding author

Correspondence to Dilina do Nascimento Marreiro.

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de Oliveira, A.R.S., Cruz, K.J.C., Morais, J.B.S. et al. Magnesium Status and Its Relationship with C-Reactive Protein in Obese Women. Biol Trace Elem Res 168, 296–302 (2015). https://doi.org/10.1007/s12011-015-0358-8

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  • DOI: https://doi.org/10.1007/s12011-015-0358-8

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