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Dietary Chitosan Supplementation Ameliorates Isoproterenol-Induced Aberrations in Membrane-Bound ATPases and Mineral Status of Rat Myocardium

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Abstract

Myocardial infarction is one of the major public concerns in both developed and developing countries. Recently, there is growing interest in potential healthcare applications of marine natural products in the field of cardiovascular research. In the present study, we have examined the membrane-stabilizing potential of marine mucopolysaccharide-chitosan in modulating the aberrations of thiol-dependent membrane-bound ATPases activities, mineral status, and cardiac diagnostic markers in isoproterenol-induced myocardial infarction condition in rats. Dietary intake of chitosan significantly (p < 0.05) counteracted the isoproterenol-induced lipid peroxidation and maintained the levels of thiol contents and cardiac biomarkers at concentrations analogous to that of normal controls in the rat myocardium. Chitosan administration also significantly mitigated isoproterenol-induced aberrations in the membrane-bound ATPase activities in the heart tissue and preserved the myocardial mineral status in serum and heart tissue of experimental rats at near normal value. The results of the present study have indicated that the salubrious effect of dietary chitosan supplementation in attenuating the experimentally induced myocardial infarction condition is probably ascribable to its antioxidant defense and membrane-stabilizing properties.

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Acknowledgments

The financial aid in the form of ICAR National Fellow from the Indian Council of Agricultural Research for Dr. R. Anandan is gratefully acknowledged. The authors thank the Director, Central Institute of Fisheries Technology, Cochin, for granting permission to publish this paper. The technical assistance rendered by Ms P.A. Jaya and Dr. G. Usha Rani is gratefully acknowledged.

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Authors and Affiliations

  1. Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), Cochin, 682029, Kerala, India

    Rangasamy Anandan, Niladri Sekhar Chatterjee, Ramalingam Sivakumar, Suseela Mathew, Kurukkan Kunnath Asha & Balaraman Ganesan

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  1. Rangasamy Anandan
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  2. Niladri Sekhar Chatterjee
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  3. Ramalingam Sivakumar
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  4. Suseela Mathew
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  5. Kurukkan Kunnath Asha
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  6. Balaraman Ganesan
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Correspondence to Rangasamy Anandan.

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Anandan, R., Chatterjee, N.S., Sivakumar, R. et al. Dietary Chitosan Supplementation Ameliorates Isoproterenol-Induced Aberrations in Membrane-Bound ATPases and Mineral Status of Rat Myocardium. Biol Trace Elem Res 167, 103–109 (2015). https://doi.org/10.1007/s12011-015-0289-4

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