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Antioxidant and Antitumor Activities of Selenium- and Zinc-Enriched Oyster Mushroom in Mice

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Abstract

Selenium and zinc are well-known essential trace elements with potent biological functions. However, the possible health benefits of the combined administration of dietary selenium and zinc have not been studied extensively. In this study, we prepared selenium- and zinc-enriched mushrooms (SZMs) containing increased levels of selenium and zinc. The effects of SZMs on antioxidant and antitumor activities were evaluated. Mice were fed with either a control diet or a diet supplemented with SZMs or sodium selenite and zinc sulfate for 6 weeks. Antioxidant capacity was investigated by measuring the activities of antioxidant enzymes and the levels of lipid peroxide products. Results showed that treatment with SZMs significantly increased the activities of glutathione peroxidase (GPx) and superoxide dismutase and decreased the levels of malondialdehyde and lipofuscin. Furthermore, using a mouse model of lung tumors, we found that SZMs significantly decreased the number of tumor nodes with an increase in the activity of GPx. SZMs had a greater effect on the increase in both antioxidant and antitumor activities than did sodium selenite and zinc sulfate. These findings suggest that SZMs may be effective for improving antioxidant capacity and preventing tumors.

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Acknowledgments

This study was supported in part by funds from the Fifth Hospital of Shijiazhuang.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Central Laboratory, Fifth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050021, China

    Huimin Yan

  2. Shijiazhuang Municipal Bureau of Health Supervision, Shijiazhuang, Hebei, 050023, China

    Hui Chang

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  1. Huimin Yan
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  2. Hui Chang
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Correspondence to Hui Chang.

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Yan, H., Chang, H. Antioxidant and Antitumor Activities of Selenium- and Zinc-Enriched Oyster Mushroom in Mice. Biol Trace Elem Res 150, 236–241 (2012). https://doi.org/10.1007/s12011-012-9454-1

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  • DOI: https://doi.org/10.1007/s12011-012-9454-1

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