Abstract
Zinc (Zn) and copper (Cu) are essential micronutrients involved in numerous metabolic reactions. They are also antagonists of the N-methyl-d-aspartate glutamate (NMDA) receptor in the central nervous system, which mediates mood, cognition, pain perception, and sleep. However, there have been few studies on the effects of Zn and Cu on sleep. A total of 126 adult women were recruited in this cross-sectional study. Zn and Cu levels in the serum and hair were measured for each subject. The participants completed the 7-day physical activity recall questionnaire and the Hospital Anxiety and Depression Scale. The mean hours of sleep were compared according to the tertiles of Zn, Cu, and Zn/Cu ratio in the serum and hair by analyses of covariance. The participants in the middle tertile of Zn and Zn/Cu ratio in the serum had significantly longer sleep duration compared to those in the lowest tertile (p < 0.05 for each). An increasing Zn/Cu ratio in the hair was associated with longer sleep hours (p = 0.026), whereas sleep duration decreased significantly from the lowest to the highest tertile of hair Cu level (p = 0.010). The largest percentage of participants with optimal sleep duration was observed in the highest tertile of Zn/Cu ratio in the serum and hair (p = 0.052 and 0.046, respectively). The results of our study suggest that Zn/Cu ratio as well as Zn or Cu levels in the serum and hair may be involved in sleep duration in adult women.
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References
Huskisson E, Maggini S, Ruf M (2007) The role of vitamins and minerals in energy metabolism and well-being. J Int Med Res 35:277–289
Prasad A, Bao B, Beck F, Kucuk O, Sarkar F (2004) Antioxidant effect of zinc in humans. Free Radic Biol Med 37:1182–1190
Gaetke LM, Chow CK (2003) Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology 189:147–163
Huskisson E, Maggini S, Ruf M (2007) The influence of micronutrients on cognitive function and performance. J Int Med Res 35:1–19
Frederickson CJ, Suh SW, Silva D, Thompson RB (2000) Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr 130:1471S–1483S
Peters S, Koh J, Choi D (1987) Zinc selectively blocks the action of N-methyl-d-aspartate on cortical neurons. Science 236:589–593
Vlachova V, Zemkova H, Vyklicky L Jr (1996) Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons. Eur J Neurosci 8:2257–2264
Campbell IG, Gustafson LM, Feinberg I (2002) The competitive NMDA receptor antagonist CPPene stimulates NREM sleep and eating in rats. Neuropsychopharmacology 26:348–357
Juhasz G, Kekesi K, Emri Z, Soltesz I, Crunelli V (1990) Sleep-promoting action of excitatory amino acid antagonists: a different role for thalamic NMDA and non-NMDA receptors. Neurosci Lett 114:333–338
Ascher P, Nowak L (1988) The role of divalent cations in the N-methyl-d-aspartate responses of mouse central neurones in culture. J Physiol 399:247–266
FAO, IAEA (1996) Trace elements in human nutrition and health. WHO, Geneva
Abdel-Mageed AB, Oehme FW (1990) A review of the biochemical roles, toxicity and interactions of zinc, copper and iron: I. Zinc Vet Hum Toxicol 32:34–39
Zhang HQ, Li N, Zhang Z, Gao S, Yin HY, Guo DM, Gao X (2009) Serum zinc, copper, and zinc/copper in healthy residents of Jinan. Biol Trace Elem Res 131:25–32
Leone N, Courbon D, Ducimetiere P, Zureik M (2006) Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology 17:308–314
Kim Y, Park E, Shin H, Kim I, Kim U, Jo W, Choi H (1994) A study of physical activity–measure methods for the field of primary care. J Korean Acad Fam Med 15:132–141
Oh S, Min K, Park D (1999) A study on the standardization of the hospital anxiety and depression scale for Koreans: a comparison of normal, depressed and anxious groups. J Korean Neuropsychiatr Assoc 38:289–296
Ford ES (2000) Serum copper concentration and coronary heart disease among US adults. Am J Epidemiol 151:1182–1188
Ito Y, Suzuki K, Sasaki R, Otani M, Aoki K (2002) Mortality rates from cancer or all causes and SOD activity level and Zn/Cu ratio in peripheral blood: population-based follow-up study. J Epidemiol 12:14–21
Philpott M, Ferguson L (2004) Immunonutrition and cancer. Mutat Res 551:29–42
Oberley LW, Buettner GR (1979) Role of superoxide dismutase in cancer: a review. Cancer Res 39:1141–1149
Magalova T, Bella V, Brtkova A, Beno I, Kudlackova M, Volkovova K (1999) Copper, zinc and superoxide dismutase in precancerous, benign diseases and gastric, colorectal and breast cancer. Neoplasma 46:100–104
Ferns GA, Lamb DJ, Taylor A (1997) The possible role of copper ions in atherogenesis: the Blue Janus. Atherosclerosis 133:139–152
Salonen JT, Salonen R, Seppanen K, Kantola M, Suntioinen S, Korpela H (1991) Interactions of serum copper, selenium, and low density lipoprotein cholesterol in atherogenesis. BMJ 302:756–760
Kato K, Li ST, Zorumski CF (1999) Modulation of long-term potentiation induction in the hippocampus by N-methyl-d-aspartate-mediated presynaptic inhibition. Neuroscience 92:1261–1272
Scheetz AJ, Constantine-Paton M (1994) Modulation of NMDA receptor function: implications for vertebrate neural development. FASEB J 8:745–752
Campbell IG, Feinberg I (1996) Noncompetitive NMDA channel blockade during waking intensely stimulates NREM delta. J Pharmacol Exp Ther 276:737–742
Arredondo M, Nunez H, Lopez G, Pizarro F, Ayala M, Araya M (2010) Influence of estrogens on copper indicators: in vivo and in vitro studies. Biol Trace Elem Res 134:252–264
Jones CE, Underwood CK, Coulson EJ, Taylor PJ (2007) Copper induced oxidation of serotonin: analysis of products and toxicity. J Neurochem 102:1035–1043
Mayer ML, Westbrook GL, Guthrie PB (1984) Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309:261–263
Young LT, Robb JC, Levitt AJ, Cooke RG, Joffe RT (1996) Serum Mg2+ and Ca2+/Mg2+ ratio in major depressive disorder. Neuropsychobiology 34:26–28
Jung K, Bang S, Choi W, Ock S, Yoon S, Song C (2007) The association between serum calcium, magnesium, and zinc levels with sleep hours in adult women. Korean J Sleep Med 9:19–24
Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA (2011) Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J 32:1484–1492
Cappuccio FP, D'Elia L, Strazzullo P, Miller MA (2010) Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 33:585–592
Cappuccio FP, D'Elia L, Strazzullo P, Miller MA (2010) Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 33:414–420
Gangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, Pickering TG, Rundle AG, Zammit GK, Malaspina D (2006) Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey. Hypertension 47:833–839
Knutson KL, Turek FW (2006) The U-shaped association between sleep and health: the 2 peaks do not mean the same thing. Sleep 29:878–879
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Hair and serum calcium and magnesium analyses were supported by TEI Korea., Ltd. according to their acceptance of our proposal of this study.
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Song, CH., Kim, YH. & Jung, KI. Associations of Zinc and Copper Levels in Serum and Hair with Sleep Duration in Adult Women. Biol Trace Elem Res 149, 16–21 (2012). https://doi.org/10.1007/s12011-012-9398-5
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DOI: https://doi.org/10.1007/s12011-012-9398-5