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Influence of Selenium on Hepatic Mitochondrial Antioxidant Capacity in Ducklings Intoxicated with Aflatoxin B1

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Abstract

The aim of the study was to investigate the effect of selenium on hepatic mitochondrial antioxidant capacity in ducklings administrated with aflatoxin B1 (AFB1). Ninety 7-day-old ducklings were randomly divided into three groups (groups I–III). Group I was used as a blank control. Group II was administered with AFB1 (0.1 mg/kg body weight). Group III was administered with AFB1 (0.1 mg/kg body weight) plus selenium (sodium selenite, 1 mg/kg body weight). All treatments were given once daily for 21 days. The results showed that the activities of mitochondrial superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR) in group II ducklings significantly decreased when compared with group I (P < 0.01). Furthermore, the content of hepatic mitochondrial malondialdehyde (MDA) significantly increased (P < 0.01). However, the activities of hepatic mitochondrial SOD, CAT, GSH-Px, and GR in group III ducklings significantly increased when compared with group II (P < 0.05). In addition, the content of hepatic mitochondrial MDA significantly decreased (P < 0.01). These results revealed that AFB1 significantly induced hepatic mitochondrial antioxidant dysfunction. However, sodium selenite could significantly ameliorate the negative effect induced by AFB1.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 38071900).

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Authors and Affiliations

  1. College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China

    Dayou Shi, Shining Guo, Rongsheng Su, Jiaqiang Pan, Yuanchao Lin & Zhaoxin Tang

  2. Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China

    Shenquan Liao

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  1. Dayou Shi
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  2. Shining Guo
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  3. Shenquan Liao
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  4. Rongsheng Su
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  5. Jiaqiang Pan
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  6. Yuanchao Lin
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  7. Zhaoxin Tang
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Corresponding author

Correspondence to Zhaoxin Tang.

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Dayou Shi, Shining Guo, and Shenquan Liao contributed equally to this work.

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Shi, D., Guo, S., Liao, S. et al. Influence of Selenium on Hepatic Mitochondrial Antioxidant Capacity in Ducklings Intoxicated with Aflatoxin B1 . Biol Trace Elem Res 145, 325–329 (2012). https://doi.org/10.1007/s12011-011-9201-z

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  • DOI: https://doi.org/10.1007/s12011-011-9201-z

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