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Cadmium Is More Toxic on Volume Bone Mineral Density than Tissue Bone Mineral Density

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Abstract

It has been showed that Cd induces low areal bone mineral density, but we do not know the effect of Cd on cubic bone density. This study was aimed to investigate the effects of Cd on volumetric bone mineral density (VBMD) and tissue bone mineral density (TBMD) in male rats. Twenty-four Sprague–Dawley male rats were randomly divided into four groups that were given cadmium chloride by subcutaneous injection at doses of 0, 0.1, 0.5, and 1.5 mg/kg body weight for 8 weeks, respectively. Then, microcomputed tomography scanning was performed on the proximal tibia, and region of interest was reconstructed using microview software. The VBMD, bone volume fraction of rats treated with 1.5 mg Cd/kg, were significantly decreased compared to control (p < 0.01). The trabecular numbers of rats exposed to Cd were all significantly decreased relative to control (p < 0.05). The trabecular separation of rats treated with 1.5 mg Cd/kg was obviously increased compared to control (p < 0.01). However, Cd had no obvious influence on TBMD. Cd induced low VBMD but not TBMD; Cd effect on bone may be related with trabecular bone loss but not with trabecular bone demineralization.

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References

  1. Wang H, Zhu G, Shi Y, Weng S, Jin T, Kong Q, Nordberg GF (2003) Influence of environmental cadmium exposure on forearm bone density. J Bone Miner Res 18:553–560

    Article  PubMed  CAS  Google Scholar 

  2. Jin T, Nordberg GF, Ye T, Bo M, Wang H, Zhu G, Kong Q, Bernard A (2004) Osteoporosis and renal dysfunction in general population exposed to cadmium in China. Environ Res 96:353–359

    Article  PubMed  CAS  Google Scholar 

  3. Åkesson A, Bjellerup P, Lundh T, Lidfeldt J, Nerbrand C, Samsioe G, Skerfving S, Vahter M (2006) Cadmium-induced effects on bone in a population-based study of women. Environ Health Perspect 114:830–834

    Article  PubMed  Google Scholar 

  4. Staessen JA, Roels HA, Emelianov D, Kuznetsova T, Thijs L, Vangronsveld J, Fagard R (1999) Environment exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Lancet 353:1140–1144

    Article  PubMed  CAS  Google Scholar 

  5. Brzóska MM, Moniuszko-Jakoniuk J (2005) Bone metabolism of male rats chronically exposed to cadmium. Toxicol Appl Pharmacol 207:195–211

    Article  PubMed  Google Scholar 

  6. Brzoska MM, Majewska K, Moniuszko-Jakoniuk J (2005) Mechanical properties of femoral diaphysis and femoral neck of female rats chronically exposed to various level of cadmium. Calcif Tiss Int 76:287–298

    Article  CAS  Google Scholar 

  7. Schoenau E (1998) Problem of bone analysis in childhood and adolescence. Pediatr Nephrol 12:420–429

    Article  Google Scholar 

  8. Genant HK, Engelke K, Fuerst T, Gluer CC, Grampp S, Harris ST, Jerqas M, Lang T, Lu Y, Majumdar S, Mathur A, Takada M (1996) Noninvasive assessment of bone mineral and structure: state of the art. J Bone Miner Res 11:707–730

    Article  PubMed  CAS  Google Scholar 

  9. Carter DR, Bouxsein ML, Marcus R (1992) New approaches for interpreting projected bone densitometry data. J Bone Miner Res 7:137–145

    Article  PubMed  CAS  Google Scholar 

  10. Holm IA (2001) Disorders of bone metabolism. In: Brook C, Clayton P, Brown R (eds) Brook’ clinical pediatric endocrinology, 5th edn. Blackwell, New York

    Google Scholar 

  11. Shane E, Silverberg SJ, Donovan D, Papadopoulos A, Staron RB, Addesso V, Jorqesen B, McGreqor C, Schulman L (1996) Osteoporosis in lung transplantation candidates with end-stage pulmonary disease. Am J Med 101:262–269

    Article  PubMed  CAS  Google Scholar 

  12. Wang X, Kammerer CM, Wheeler VW, Patrick AL, Bunker CH, Zmuda JM (2007) Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: the Tobago Family Health Study. J Bone Miner Res 22:527–536

    Article  PubMed  Google Scholar 

  13. Jiang Y, Zhao J, White DL, Genant HK (2000) Micro CT and micro MR imaging of 3D architecture of animal skeleton. J Musculoskelet Neuronal Interact 1:45–51

    PubMed  CAS  Google Scholar 

  14. Seeman E (1997) From density to structure: growing up and growing old on the surfaces of bone. J Bone Miner Res 12:509–521

    Article  PubMed  CAS  Google Scholar 

  15. Witmer L, Ridgely R (2006) Bone mineral density calculation in microview. http://www.oucom.ohiou.edu/ou-microct. Accessed 28 Sept 2006

  16. Liu SP, Liao EY, Chen J, Yang SM, Li JW, Sheng ZF, Mo H, Wu XP, Yao L, Dai RC (2009) Effects of methylprednisolone on bone mineral density and microarchitecture of trabecular bones in rats with administration time and assessed by micro-computed tomography. Acta Radiol 50:93–100

    Article  PubMed  CAS  Google Scholar 

  17. Rauch F, Schoenau E (2001) Changes in bone density during childhood and adolescence: an approach based on bone’s biological organization. J Bone Miner Res 16:597–604

    Article  PubMed  CAS  Google Scholar 

  18. Khosla S, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, Riggs BL (2005) Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men. J Bone Miner Res 20:730–740

    Article  PubMed  Google Scholar 

  19. Petit MA, Beck TJ, Kontulainen SA (2005) Examining the developing bone: what do we measure and how do we do it? J Musculoskelet Neuronal Interact 5:213–224

    PubMed  CAS  Google Scholar 

  20. Brzóska MM, Majewska K, Moniuszko-Jakoniuk J (2004) Mineral status and mechanical properties of lumbar spine of female rats chronically exposed to various levels of cadmium. Bone 34:1180–1191

    Article  Google Scholar 

  21. Gur E, Waner T, Barushka-Eizik O, Oron U (1995) Effect of cadmium on bone repair in young rats. Toxicol Enviro Health 45:249–260

    Article  CAS  Google Scholar 

  22. Hiratsuka H, Katsuta O, Toyota N, Tsuchitani M, Marumo F, Umemura T (1997) Iron deposition at mineralization fronts and osteoid formation following chronic cadmium exposure in ovariectomized rats. Toxicol Appl Pharmacol 143:348–356

    Article  PubMed  CAS  Google Scholar 

  23. Uriu K, Morimoto I, Kai K, Okada Y, Qie YL, Okimoto N, Kaizu K, Nakamura T, Eto S (2000) Uncoupling between bone formation and resorption in ovariectomized rats with chronic cadmium exposure. Toxicol Appl Pharmacol 164:264–272

    Article  PubMed  CAS  Google Scholar 

  24. Blumenthal NC, Cosma V, Skyler D, LeGeros J, Walters M (1995) The effect of cadmium on the formation and properties of hydroxyapatite in vitro and its relation to cadmium toxicity in the skeletal system. Calcif Tissue Int 56:316–322

    Article  PubMed  CAS  Google Scholar 

  25. Mulder L, Koolstra JH, Weijs WA, Van Eijden TM (2005) Architecture and mineralization of developing trabecular bone in the pig mandibular condyle. Anat Rec A Discov Mol Cell Evol Biol 285:659–667

    PubMed  Google Scholar 

  26. Comelekoglu U, Yalin S, Bagis S, Ogenler O, Sahin NO, Yildiz A, Banu C, Hatungil R, Turac A (2007) Low-exposure cadmium is more toxic on osteoporotic rat femoral bone: mechanical, biochemical, and histopathological evaluation. Ecotoxicol Environ Safety 66:267–271

    Article  PubMed  CAS  Google Scholar 

  27. Bodo M, Balloni S, Lumare E, Bacci M, Calvitti M, Dell’Omo M, Murgia N, Marinucci L (2009) Effects of sub-toxic cadmium concentrations on bone gene expression program: results of an in vitro study. Toxicol In Vitro 24:1670–1680

    Article  Google Scholar 

  28. Legrand E, Chappard D, Pascaretti C, Duquenne M, Krebs S, Rohmer V, Basle MF, Audran M (2000) Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis. J Bone Miner Res 15:13–19

    Article  PubMed  CAS  Google Scholar 

  29. Audran M, Chappard D, Legrand E, Libouban H, Baslé MF (2001) Bone microarchitecture and bone fragility in men: DXA and histomorphometry in humans and in orchidectomized rat model. Calcif Tiss Int 69:214–217

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Radiation Medicine, Fudan University, 200032, Shanghai, China

    Xiao Chen, Guoying Zhu & Shuzhu Gu

  2. School of Public Health, Fudan University, 200032, Shanghai, China

    Taiyi Jin

  3. Shanghai Public Health Clinic Center, 201508, Shanghai, China

    Boyin Qin & Wenjiang Zhou

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  1. Xiao Chen
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  2. Guoying Zhu
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  3. Taiyi Jin
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  6. Shuzhu Gu
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Correspondence to Guoying Zhu.

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Chen, X., Zhu, G., Jin, T. et al. Cadmium Is More Toxic on Volume Bone Mineral Density than Tissue Bone Mineral Density. Biol Trace Elem Res 144, 380–387 (2011). https://doi.org/10.1007/s12011-011-9106-x

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  • DOI: https://doi.org/10.1007/s12011-011-9106-x

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