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Oxidative Stress in the Liver of Mice Caused by Intraperitoneal Injection with Lanthanoides

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Abstract

In order to study the mechanisms underlying the effects of lanthanoid (Ln) on the liver, ICR mice were injected with LaCl3, CeCl3, and NdCl3 at a dose of 20 mg/kg BW into the abdominal cavity daily for 14 days. We then examined oxidative stress-mediated responses in the liver. The increase of lipid peroxide in the liver produced by Ln suggested an oxidative attack that was activated by a reduction of antioxidative defense mechanisms as measured by analyzing the activities of superoxide dismutase, catalase, and ascorbate peroxidase, as well as antioxidant levels such as glutathione and ascorbic acid, which were greatest in Ce3+ treatment, medium in Nd3+, and least in La3+. Our results also implied that the oxidative stress in the liver caused by Ln likely is Ce3+ > Nd3+ >La3+, but the mechanisms need to be further studied in future.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (grant no. 30901218), by the Medical Development Foundation of Soochow University of China (grant no. EE120701), and by the National New Ideas Foundation of Student of China (grant no. 57315427, 57315927).

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Authors and Affiliations

  1. Medical College of Soochow University, Suzhou, 215123, People’s Republic of China

    Min Fei, Na Li, Yuguan Ze, Jie Liu, Xiaolan Gong, Yanmei Duan, Xiaoyang Zhao, Han Wang & Fashui Hong

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  1. Min Fei
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  2. Na Li
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  3. Yuguan Ze
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  4. Jie Liu
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  5. Xiaolan Gong
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  6. Yanmei Duan
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  7. Xiaoyang Zhao
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  8. Han Wang
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  9. Fashui Hong
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Correspondence to Fashui Hong.

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Min Fei, Na Li, Yuguan Ze, Jie Liu, and Xiaolan Gong contributed equally to this work.

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Fei, M., Li, N., Ze, Y. et al. Oxidative Stress in the Liver of Mice Caused by Intraperitoneal Injection with Lanthanoides. Biol Trace Elem Res 139, 72–80 (2011). https://doi.org/10.1007/s12011-010-8638-9

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  • DOI: https://doi.org/10.1007/s12011-010-8638-9

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