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Chromium, Cadmium, and Lead Levels in Urine of Children with Autism and Typically Developing Controls

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Abstract

Although potentially harmful effects of heavy metals are well known, limited numbers of studies exist regarding their relationship with autism. The aim of this study was to investigate urine levels of some heavy metals such as of chromium (Cr), cadmium (Cd), and lead (Pb) in children with autism and healthy subjects. Urine levels of Cr, Cd, and Pb were measured by atomic absorption spectrometry in 30 children with autism and compared with 20 healthy controls. Urine Cd and Pb levels were found as significantly decreased in children with autism compared to healthy subjects (p < 0.05). On the other hand, urine Cr levels were significantly higher in children with autism than healthy subjects (p < 0.05). This study suggested that autism may be associated with significant decrease in excretion rate of Cd and Pb and a significant increase excretion rate in the levels of Cr in the urine. These results have indicated that further studies are warranted for investigation of possible roles of heavy metals in autism.

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Authors and Affiliations

  1. Gülhane Military Medical Faculty Child Psychiatry Department, Etlik 06018, Ankara, Turkey

    Özgür Yorbik

  2. Gülhane Military Medical Faculty Biochemistry Department, Etlik 06018, Ankara, Turkey

    İsmail Kurt, Adnan Haşimi & Özlem Öztürk

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  1. Özgür Yorbik
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  2. İsmail Kurt
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  4. Özlem Öztürk
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Correspondence to Özgür Yorbik.

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Yorbik, Ö., Kurt, İ., Haşimi, A. et al. Chromium, Cadmium, and Lead Levels in Urine of Children with Autism and Typically Developing Controls. Biol Trace Elem Res 135, 10–15 (2010). https://doi.org/10.1007/s12011-009-8494-7

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  • DOI: https://doi.org/10.1007/s12011-009-8494-7

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