Skip to main content
SpringerLink
Log in

The Oxidative Damage in Lung of Mice Caused By Lanthanoide

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

This study was performed with the objective of assessing the antioxidant response of the lung of mice to different rare earths. LaCl3, CeCl3, and NdCl3 at a higher dose of 20 mg/kg body weight were injected into the nasal cavity of ICR mice for consecutive 14 days, respectively. The increase of pulmonary lipids peroxide produced by Ln suggested an oxidative attack that was activated by a reduction of antioxidative defense mechanisms as measured by analyzing the activities of superoxide dismutase, catalase, ascorbate peroxidase, and total antioxidant capacity, as well as antioxidant levels such as glutathione and ascorbic acid, which were greatest in Ce3+ treatment, medium in Nd3+, and least in La3+. It implied that the antioxidative responses of lung may be involved in 4f shell and alternable valence properties of Ln-induced lung toxicity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Nair RR, Preeta R, Smitha G, Adiga I (2003) Variation in mitogenic response of cardiac and pulmonary fibroblasts to Cerium. Biol Trace Elem Res 94:237–246

    Article  PubMed  CAS  Google Scholar 

  2. Guo BS, Zhu WM, Xiong BK, Ji YJ, Liu Z, Wu ZM (1990) Application of rare earths in agriculture. China Agricultural Science and Technology Press, Beijing, pp 209–257 in Chinese

    Google Scholar 

  3. Ni JZ (2002) Bioinorganic chemistry of rare earths. Science Press, Beijing, pp 8–343 in Chinese

    Google Scholar 

  4. Liu C, Hong FS, Zheng L, Tang P, Wang ZG (2004) Effects of rare earth elements on vigor enhancement of aged spinach seeds. J Rare Earths 22(4):547–552

    Google Scholar 

  5. Liu XQ, Su MY, Liu C, Hong FS (2007) Effects of 4f electron characteristic and alternation valence of rare earths on photosynthesis: regulating distribution of energy and activities of spinach chloroplast. J Rare Earths 25(4):495–501

    Article  Google Scholar 

  6. Yang WD, Wang T, Lei HY, Yang YS (1999) Study on the hepatic toxicity of cerous nitrate in rats. J Hyg Res 28(2):91–94 Abstract in English

    CAS  Google Scholar 

  7. Huang KX, Li DM, Nie YX (2002) Effects of low dosage lanthanum nitrate on defence function of free radical in mice kidney. J Chin Rare Earth Soc 20:190–192

    Google Scholar 

  8. Liu Y, Chen D, Chen AJ, Liu B, Nie YX (2001) Antioxidation effect of low dose of“Changle”and lanthanum nitrate on liver in rats. J N Bethune Univ Med Sci 27(1):14–16 Abstract in English

    CAS  Google Scholar 

  9. Zhu WF, Xu SQ, Shao PP, Zhang H, Feng J, Wu DL, Yang WJ (1997) Investigation on intake allowance of rare earth—a study on bio-effect of rare earth in South Jiangxi. Chin Environ Sci 17(1):64–66

    Google Scholar 

  10. Zhang H, Feng J, Zhu WF (1999) Characteristic of rare earth distribution in biologic chains of rare earth-rich background regions. J Rare Earths 17(4):356–358

    Google Scholar 

  11. Chen ZY (1999) Reflection on the biological effects of rare earth and the cumulative impacts of its agricultural application. Rural Eco-Environ 15(3):44–48

    Google Scholar 

  12. Yuan BJ, Liao MY, Li B (2007) Drug toxicological method and technic. Chemical Industry Press, Beijing, pp 215–217 Abstract in English

    Google Scholar 

  13. Shen ZG, Lei HY, Wei Q, Yang XF, Zuang ZX, Yang YS (2001) Effect of Ce3+ on the activities of ATPase of hepatocytes. Chin Rare Earths 22(1):35–37 Abstract in English

    Google Scholar 

  14. Oliveira CP, Lopasso FP, Laurindo FR, Leitao RM, Laudanna AA (2001) Protection against liver ischemia-reperfusion injury in rats by silymarin or verapamil. Transplant Proc 33:3010–3014

    Article  PubMed  CAS  Google Scholar 

  15. Asatiani N, Sapojnikova N, Abuladze M, Kartvelishvili T, Kulikova N, Kiziria E, Namchevadze E, Holman HY (2004) Effects of Cr(VI) long-term and low-dose action on mammalian antioxidant enzymes (an in vitro study). J Inorg Biochem 98:490–496

    Article  PubMed  CAS  Google Scholar 

  16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275

    PubMed  CAS  Google Scholar 

  17. Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302–310

    Article  PubMed  CAS  Google Scholar 

  18. Beauchamp C, Fridovich I (1971) Superoxide dismutase: improved assays and assay applicable to acrylamide gels. Anal Biochem 44:276–286

    Article  PubMed  CAS  Google Scholar 

  19. Claiborne A (1985) Catalase activity. In: Greenwaid RA (ed) Handbook of methods for oxygen free radical research. CRC, Boca Raton, FL

    Google Scholar 

  20. Reuveni R, Shimoni M, Karchi Z, Kuc J (1992) Peroxidase activity as a biochemical marker for resistance of muskmelon (Cucumis melo) to seudoperno spora cubensis. Phytopathology 82:749–753

    Article  CAS  Google Scholar 

  21. Hissin PJ, Hilf R (1976) A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214–226

    Article  PubMed  CAS  Google Scholar 

  22. Jacques-Silva MC, Nogueira CW, Broch LC, Flores EM, Rocha JBT (2001) Diphenyl diselenide and ascorbic changes deposition of selenium and ascorbic in liver and brain of mice. Pharmacol Toxicol 88:119–125

    Article  PubMed  CAS  Google Scholar 

  23. Liu JM, Meng XT, Chen D, Wang XM, Nie YX (2003) Effect of Changle on levels of IL-2 and γ-IFN of spleniclymphocytes in rats. J Chin Rare Earth Soc 21(3):328–330

    CAS  Google Scholar 

  24. Fridovich I (1978) The biology in oxygen radical. Science 201:875–880

    Article  PubMed  CAS  Google Scholar 

  25. John G, Scandalios JG (1993) Oxygen stress and superoxide dismutase. Plant Physiol 101:7–12

    Google Scholar 

  26. Wang CR, Min L, Xie Y, Liu CM (2004) Effect of rare earth holmium ion on antioxidant enzyme activity of liver in mice. J Health Toxicol 18:243–245 Abstract in English

    CAS  Google Scholar 

  27. Wang CR, Wu W, He M, Bo J (2004) Effect of holmium nitrate solution on nucleus anomaly of bone marrow cells and three antioxidant enzymes' activities of liver in mice. Chinese Rare Earth 25:36–40 Abstract in English

    CAS  Google Scholar 

  28. Hao SX, Lv HM (2006) Advance in studies on rare earth against oxidation in organism. Chin Rare Earths 27:79–84 Abstract in English

    Google Scholar 

  29. Li SL, Nie YX, Huang KX, Chen X (2001) Effect of rare earth on antioxidant ability of gastric mucosa of rats. Journal of Jilin Military Medical College Fourth Military Medical University 23:3–4 Abstract in English

    Google Scholar 

  30. Zhang ZG, Shen XY, Xu XL, Wu AF (2004) Effects of cerium nitrate on learning-memmory and antioxidantion of rats. Journal of Zhejiang Normal University (Natural Sciences) 24:167–170 Abstract in English

    Google Scholar 

  31. Huang KX, Li DM, Nie YX, Li SL, Huang KJ (2003) Effects of administration of low dosage La (NO3)3 on SOD and LPO in mice heart. Stud Trace Elem Health 20:1–2 Abstract in English

    CAS  Google Scholar 

  32. Shimada H, Nagano M, Funakoshi T, Kojima S (1996) Pulmonary toxicity of systemic terbium chloride in mice. J Toxicol Environ Health 48:81–92

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (30800068) and by the Junzheng Scholar Foundation.

Author information

Authors and Affiliations

  1. Medical College of Soochow University, Suzhou, 215123, People’s Republic of China

    Na Li, Sisi Wang, Jie Liu, Linglan Ma, Yanmei Duan & Fashui Hong

Authors
  1. Na Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sisi Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jie Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Linglan Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yanmei Duan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fashui Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fashui Hong.

Additional information

N. Li, S. Wang, and J. Liu contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, N., Wang, S., Liu, J. et al. The Oxidative Damage in Lung of Mice Caused By Lanthanoide. Biol Trace Elem Res 134, 68–78 (2010). https://doi.org/10.1007/s12011-009-8448-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-009-8448-0

Keywords

Search

Navigation