Abstract
The objective of the present study is to investigate how low-dose zinc supplementation for 2 weeks in the post-menopausal period influences levels of estrogen and progesterone in the serum. The study registered 32 natural menopause patients, who were allocated to four groups with equal number of patients. Group 1, control group, which was not subjected to any procedure. Group 2, the group that was supplemented with 15 mg/day zinc sulfate for 2 weeks. Group 3, the group that was given hormone replacement therapy (0.625 mg estrogen + 5 mg medroxyprogesterone acetate/day) for 2 weeks. Group 4, the group that received hormone replacement therapy (0.625 mg estrogen + 5 mg medroxyprogesterone acetate/day) and zinc sulfate (15 mg/day) for 2 weeks. Blood samples were collected twice from each subject, once at the beginning of the study, and once at the end of the 4-week procedure to determine estrogen (E2) and progesterone levels. Variance analysis was employed in the statistical evaluation of data. Level of significance was set at p < 0.05. No significant difference was found between the estrogen and progesterone levels of groups 1 and 2. Groups 3 and 4 had higher estrogen and progesterone levels than groups 1 and 2 (p < 0.05). Estrogen and progesterone levels in groups 3 and 4 were not different. Results of the study show that low-dose zinc supplementation to post-menopausal women for 2 weeks does not have a significant effect on the concerned parameters.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Prasad AS (1985) Clinical manifestations of zinc deficiency. Ann Rev Nutr 5:341–363
Vallee BL, Falchuk KH (1993) The biochemical basis of zinc physiology. Physiol Rev 73:341–363
Igarashi A, Yamaguchi M (1999) Increase in bone protein components with healing rat fractures: enhancement by zinc treatment. Int J Mol Med 4:615–620
Saltman PD, Strause LG (1993) The role of trace minerals in osteoporosis. J Am Coll Nutr 12:384–389
Contreras F, Simonovis N, Fovilioux C et al (2002) Zincuria and zincemia in postmenopausal osteoporosis. International Congress Series 1237:219–229
Fushimi H, Inoue T, Yamada Y et al (1993) Zinc deficiency exaggerates diabetic osteoporosis. Diabetes Res Clin Pract 20:191–196
Strause L, Saltman P, Smith KT, Bracker M, Andon MB (1994) Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr 124:1060–1064
Szathmári M, Steczek K, Szucs J, Hollo I (1993) Zinc excretion in osteoporotic women. Orv Hetil 134:911–914
Herzberg M, Lusky A, Blonder J, Frenkel Y (1996) The effect of estrogen replacement therapy on zinc in serum and urine. Obstet Gynecol 87:1035–1040
Yamaguchi M, Gao YH (1998) Anabolic effects of genistein and genistin on bone metabolism in femoral-metaphyseal tissues of elderly rats: the genistein effect is enhanced by zinc. Mol Cell Biochem 178:377–382
Segawa Y, Tsuzuike N, Tagashira E, Yamaguchi M (1993) Preventive effect of beta- alanyl-L-histidino zinc on the deterioration of bone metabolism in ovariectomized rats. Biol Pharm Bull 16:486–489
Yamaguchi M, Kishi S (1993) Prolonged administration of beta alanyl-L- histidino zinc prevents bone loss in ovariectomized rats. Jpn J Pharmacol 63:203–207
Kishi S, Segawa Y, Yamaguchi M (1994) Histomorphological confirmation of the preventive effect of beta-alanyl-L-histidinato zinc on bone loss in ovariectomized rats. Biol Pharm Bull 17:862–865
Hafiez AA, el-Kirdassy ZH, el-Malkh NM, el-Zayat EM (1990) Role of zinc in regulating the testicular function. Part 3. Histopathological changes induced by dietary zinc deficiency in testes of male albino rats. Nahrung 34:65–73
Nishi Y (1996) Zinc and growth. J Am Coll Nutr 15:340–344
Om AS, Chung KW (1996) Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. J Nutr 126:842–848
Humeny A, Bokenkamp D, Thole H (1999) The HDQVH-motif in domain E of the estradiol receptor alpha is responsible for zinc-binding and zinc-induced hormone release. Mol Cell Endocrinol 153:71–78
O’Dell BL, Emery M, Xia J, Browning JD (1997) In vitro addition of glutathione to blood from zinc-deficient rats corrects platelet defects: impaired aggregation and calcium uptake. J Nutr Biochem 8:346–350
Kimmel PL, Watkins DW, Gubish CT, Slatopolsky E, Langman CB (1991) Zinc nutritional status modulates the 1,25-(OH)2D response in uremic rats. Miner Electrolyte Metab 17:307–314
Baltaci AK, Sunar F, Mogulkoc R, Oztekin E (2004) Effect of zinc deficiency and supplementation on lipid peroxidation of renal tissue in ovariectomized rats. Biol Trace Elem Res 101:231–239
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sunar, F., Gormus, Z.I., Baltaci, A.K. et al. The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women. Biol Trace Elem Res 126 (Suppl 1), 11–14 (2008). https://doi.org/10.1007/s12011-008-8211-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12011-008-8211-y