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Effect of Homocysteine on Bone Mineral Density of Rats

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Abstract

The relationship between plasma levels of homocysteine (Hcy) and femur bone mineral density (BMD) was studied in Wistar rats. After 8 weeks of treatment with 0.5 and 1.0 g kg−1 day−1 l-methionine the mean plasma levels of Hcy were 7.67 ± 1.25 and 61.2 ± 11.4 μmol/l, respectively. Only rats treated with the higher dose had Hcy levels significantly higher than those of controls, 6.38 ± 0.90 μmol/l (p < 0.001). Dual Energy X-ray Absorptiometry was used to measure the BMD, which was significantly lower only in the animals with the highest plasma levels of Hcy (p < 0.001). This led us to conclude that increased levels of Hcy are associated with risk of decreased BMD.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Süleyman Demirel University School of Medicine, Isparta, 32260, Turkey

    Feray Soyupek & Sedat Yildiz

  2. Department of Nuclear Medicine, School of Medicine, Süleyman Demirel University, Isparta, Turkey

    Sureyya Cerci, Mustafa Yildiz & Burcin Gumus

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  1. Feray Soyupek
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  2. Sureyya Cerci
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  3. Sedat Yildiz
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  4. Mustafa Yildiz
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  5. Burcin Gumus
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Correspondence to Feray Soyupek.

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Soyupek, F., Cerci, S., Yildiz, S. et al. Effect of Homocysteine on Bone Mineral Density of Rats. Biol Trace Elem Res 118, 255–259 (2007). https://doi.org/10.1007/s12011-007-0034-8

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  • DOI: https://doi.org/10.1007/s12011-007-0034-8

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