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Synthesis and Antibacterial Activity of Novel 5,5′-(Pyridine-2,6-Diyl)bis(4-Arylideneamino-3-Mercapto-1,2,4-Triazole)-Related Derivatives

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Abstract

The reaction of 5,5′-(pyridine-2,6-diyl)bis(4-amino-3-mercapto-1,2,4-triazole) with various aromatic aldehydes in acetic acid yielded the corresponding 5,5′-(pyridine-2,6-diyl)bis(4-arylideneamino-3-mercapto-1,2,4-triazole) derivatives. The structures of the synthesized compounds as well as their intermediates were confirmed by elemental analysis, infrared spectra, 1H NMR spectra and mass spectra studies. All the synthesized title compounds were screened for their antibacterial activities, and the preliminary results revealed that some of them showed good activities against Escherichia coli and Pseudomonas aeruginosa.

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Acknowledgments

The authors are grateful for the financial support of the National Natural Science Foundation of China (no. J1103312; no. 21341010), the Natural Science Foundation of Hunan Province (no. 11JJ5005), and the Innovative Research Team in University (no. IRT1238) as well as the Science and Technology Project of Hunan Provincial Science and Technology Department (no. 2012GK3156). We also thank the Hunan University of Chinese Medicine (HNUCM) for providing the antibacterial screening and Dr. William Hickey, the US professor of HRM, for the English editing on this paper.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

    Haihua Xiao, Pingliang Li, Ruixia Li, Limin Wu & Dongcai Guo

  2. Guangzhou Mechanical Engineering Research Institute Co., Ltd, Guangzhou, 510700, China

    Pingliang Li

  3. Hunan Province People’s Hospital, Changsha, 410005, China

    Jinhui Hu

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  1. Haihua Xiao
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  2. Pingliang Li
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  3. Jinhui Hu
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  4. Ruixia Li
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  5. Limin Wu
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  6. Dongcai Guo
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Correspondence to Dongcai Guo.

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Xiao, H., Li, P., Hu, J. et al. Synthesis and Antibacterial Activity of Novel 5,5′-(Pyridine-2,6-Diyl)bis(4-Arylideneamino-3-Mercapto-1,2,4-Triazole)-Related Derivatives. Appl Biochem Biotechnol 172, 2188–2196 (2014). https://doi.org/10.1007/s12010-013-0657-5

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  • DOI: https://doi.org/10.1007/s12010-013-0657-5

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