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Effect of the Oral Intake of Probiotic Pediococcus acidilactici BA28 on Helicobacter pylori Causing Peptic Ulcer in C57BL/6 Mice Models

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Abstract

Probiotic lactic acid bacteria are being proposed to cure peptic ulcers by reducing colonization of Helicobacter pylori within the stomach mucosa and by eradicating already established infection. In lieu of that, in vitro inhibitory activity of pediocin-producing probiotic Pediococcus acidilactici BA28 was evaluated against H. pylori by growth inhibition assays. Further, chronic gastritis was first induced in two groups of C57BL/6 mice by orogastric inoculation with H. pylori with polyethylene catheter, and probiotic P. acidilactici BA28 was orally administered to study the eradication and cure of peptic ulcer disease. H. pylori and P. acidilactici BA28 were detected in gastric biopsy and fecal samples of mice, respectively. A probiotic treatment with P. acidilactici BA28, which is able to eliminate H. pylori infection and could reverse peptic ulcer disease, is being suggested as a co-adjustment with conventional antibiotic treatment. The study provided an evidence of controlling peptic ulcer disease, by diet modulation.

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References

  1. Correia, M., Michel, V., Matos, A. A., Carvalho, P., Oliveira, M. J., Ferreira, R. M., et al. (2012). PLoS ONE, 7(4), e35072. doi:10.1371/journal.pone.0035072.

    Article  CAS  Google Scholar 

  2. Kuster, J. G., Vliet, A. H. M., & Kuipers, E. J. (2006). Clinical Microbiology Reviews, 19(3), 449–490.

    Article  Google Scholar 

  3. Prasad, S., Mathan, M., Chandy, G., Rajan, D. P., Venkateswaran, S., Ramakrishna, B. S., et al. (1994). Journal of Gastroenterology and Hepatology, 9, 501–506.

    Article  CAS  Google Scholar 

  4. Kang, G., Rajan, D. P., Patra, S., Chacko, A., & Mathan, M. M. (1999). Indian Journal Medical Research, 110, 86–90.

    CAS  Google Scholar 

  5. Jais, M., & Barua, S. (2004). Journal of Communication Disorders, 36, 132–135.

    Google Scholar 

  6. NIH. (1994). Journal of the American Medical Association, 272, 659.

    Google Scholar 

  7. Megraud, F., Bonnet, F., Garnier, M., & Lamouliatte, H. (1985). Journal of Clinical Microbiology, 22, 1007–1010.

    CAS  Google Scholar 

  8. Lopez-Brea, M., Alarcon, T., Domingo, D., & Diaz- Reganon, J. (2008). Journal of Antimicrobial Chemotherapy, 61, 139–142.

    Article  CAS  Google Scholar 

  9. Karen Collins, R. D. (2007). American Institute Cancer Research, 50(7), 1365–1374.

    Google Scholar 

  10. Ljungh, A., & Wadstrom, T. (2006). Current Issues in Intestinal Microbiology, 7, 73–89.

    CAS  Google Scholar 

  11. Reid, G., Beuerman, D., Heinemann, C., & Bruce, A. W. (2001). FEMS Immunology and Medical Microbiology, 32, 37–41.

    Article  CAS  Google Scholar 

  12. Reid, G., & Bruce, A. W. (2006). World Journal of Urology, 24, 28–32.

    Article  Google Scholar 

  13. Falagas, M. E., Betsi, G. I., & Tokas, T. (2006). Journal of Microbial Information, 12, 2772.

    Google Scholar 

  14. Kaur, B., Balgir, P. P., Mittu, B., Chauhan, A., Kumar, B., & Garg, N. (2013). American Journal of Drug Diseases Development, 3(1), 1–12. doi:10.3923/ajdd.2013.

    Google Scholar 

  15. Szajewska, H., & Mrukowicz, J. Z. (2005). Paediatric Drugs, 7, 111–122.

    Article  Google Scholar 

  16. Chenoll, E., Casinos, B., Bataller, E., Astals, P., & Echevarria, P. J. (2011). Applied and Environmental Microbiology, 77, 1335–1343.

    Article  CAS  Google Scholar 

  17. Lin, W. H., Wu, C. R., Fang, T. J., Guo, J. T., Huang, S. Y., Lee, M. S., et al. (2011). Journal of the Science of Food and Agriculture, 91, 1424–1431.

    Article  CAS  Google Scholar 

  18. Kaur, B., Garg, N., Sachdev, A., Kumar, B., Mittu, B., & Chauhan, A. (2012). Open Access Scientific Reports, 1(6), 323.

    Google Scholar 

  19. Kaur, B. and Garg, N. (2013) Mintage Journal Pharmaceutical Medicine Science 17–20.

  20. Yang, R., Johnson, M. C., & Ray, B. (1992). Applied and Environmental Microbiology, 58, 3355.

    CAS  Google Scholar 

  21. Pucci, M. J., Vedamuthu, E. R., Kunka, B. S., & Vandenbergh, P. A. (1988). Applied and Environmental Microbiology, 54, 2349.

    CAS  Google Scholar 

  22. Toba, T., Yoshioka, E., & Itoh, T. (1991). Letters in Applied Microbiology, 12, 106–108.

    Article  CAS  Google Scholar 

  23. Parisi, J. T., Baldwin, J. N., & Sottile, M. (1973). Applied Microbiology, 25(4), 558–561.

    CAS  Google Scholar 

  24. Lee, A., O’Rourke, J., Ungria, M., Robertson, B., Daskalopoulos, G., & Dixon, M. F. (1997). Gastroenterology, 112, 1386–1397.

    Article  CAS  Google Scholar 

  25. Ferrero, R., Thiberge, J., Huerre, M., & Labigne, A. (1998). Infection and Immunity, 66, 1349–1355.

    CAS  Google Scholar 

  26. Eaton, K. A., Radin, M. J., & Krakowka, S. (1995). Veterinary Pathology, 32, 489–497.

    Article  CAS  Google Scholar 

  27. Patel, S. K., Pratap, C. B., Verma, A. K., Jain, A. K., Dixit, V. K., & Nath, G. (2013). World Journal of Gastroenterology, 19(7), 1056–1067.

    Article  Google Scholar 

  28. Smoot, D. T. (1997). Gastroenterology, 113, 31–34.

    Article  Google Scholar 

  29. Kim, T. S., Hur, J. W., Yu, M. A., Cheigh, C. I., Kim, K. N., Hwang, J. K., et al. (2003). Journal of Food Protection, 66(1), 3–12.

    CAS  Google Scholar 

  30. Simova, E. D., Beshkova, D. B., & Dimitrov, Z. H. P. (2009). Journal of Applied Microbiology, 106(10), 692–701.

    Article  CAS  Google Scholar 

  31. Pingitore, E. V., Salvucci, E., Sesma, F., & Nader-Macías, M. E. (2007). Communicating Current Research Educational Topics Trends Applied Microbiology, 1, 557–568.

    Google Scholar 

  32. Cats, A., Kuipers, E. J., Bosschaert, M. A. R., Pot, R. G. J., Vandenbroucke-Grauls, C. M. J. E., & Kusters, J. G. (2003). Alimentary Pharmacology and Therapeutics, 17, 429–435.

    Article  CAS  Google Scholar 

  33. Motlagh, A. M., Johnson, M. C., & Ray, B. (1991). Journal of Food Protection, 54, 873–878.

    CAS  Google Scholar 

  34. Mahler, M., Janke, C., Wagner, S., & Hedrich, H. J. (2002). Scandinavian Journal of Gastroenterology, 37, 267–278.

    Article  CAS  Google Scholar 

  35. Zhou, J. S., Shu, Q., Rutherfurd, K. J., Prasad, J., Birtles, M. J., Gopal, P. K., et al. (2000). International Journal of Food Microbiology, 56, 87–96.

    Article  CAS  Google Scholar 

  36. Matsuzaki, T., Yamazaki, R., Hashimoto, S., & Yokokura, T. (1998). Journal of Dairy Science, 81, 48–53.

    Article  CAS  Google Scholar 

  37. Matsuzaki, T., & Chin, J. (2000). Immunology and Cell Biology, 78, 67–73.

    Article  CAS  Google Scholar 

  38. Kirjavainen, P. V., El-Nezami, H. S., Salminen, S. J., Ahokas, J. T., & Wright, P. F. (1999). FEMS Immunology and Medical Microbiology, 26, 131–135.

    Article  CAS  Google Scholar 

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Acknowledgments

Authors acknowledge the contribution extended by Mrs. Nimpi Samplay, Department of Pharmacology, CT Institute, Jalandhar, Punjab, India during animal experimentation.

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Authors and Affiliations

  1. Department of Biotechnology, Punjabi University, Patiala, 147002, Punjab, India

    Baljinder Kaur, Neena Garg, Atul Sachdev & Balvir Kumar

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  1. Baljinder Kaur
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  2. Neena Garg
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  3. Atul Sachdev
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  4. Balvir Kumar
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Correspondence to Baljinder Kaur.

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Kaur, B., Garg, N., Sachdev, A. et al. Effect of the Oral Intake of Probiotic Pediococcus acidilactici BA28 on Helicobacter pylori Causing Peptic Ulcer in C57BL/6 Mice Models. Appl Biochem Biotechnol 172, 973–983 (2014). https://doi.org/10.1007/s12010-013-0585-4

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  • DOI: https://doi.org/10.1007/s12010-013-0585-4

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