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Endoscopic Ultrasound-Guided Biliary Drainage: a Review

  • Endoscopy (I Waxman, Section Editor)
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Opinion statement

Endoscopic retrograde cholangiography (ERCP) has become the standard tool for diagnosis and treatment of patients with biliary obstruction. However, despite the reported success rate of >90 % in expert centers, the common bile duct may still be occasionally inaccessible due to anatomical or technical issues. Over the past decade, endoscopic ultrasound-guided biliary drainage (EUS-BD) has emerged as an effective alternative over percutaneous transhepatic biliary drainage (PTBD) or surgical bypass for biliary drainage after unsuccessful ERCP. EUS-BD includes rendezvous techniques (EUS-RV), EUS-guided choledochoduodenostomy (EUS-CDS), and EUS-guided hepatogastrostomy (EUS-HGS). Published data demonstrated high success rates especially for EUS-CDS and EUS-HGS. Complication rates, however, are also higher in these two techniques. The indications and anatomical requirements for the three techniques differ and should be considered complementary to each other. Most reported studies only included a small number of patients, and larger-scaled randomized trials are required to establish the efficacy among various EUS techniques and to compare to traditional means of radiological or surgical drainage.

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  1. Smith AC, Dowsett JF, Russell RC, Hatfield AR, Cotton PB. Randomised trial of endoscopic stenting versus surgical bypass in malignant low bile duct obstruction. Lancet. 1994;344:1655–60.

    Article  CAS  PubMed  Google Scholar 

  2. Lai EC, Mok FP, Tan ES, et al. Endoscopic biliary drainage for severe acute cholangitis. N Engl J Med. 1992;326:1582–6.

    Article  CAS  PubMed  Google Scholar 

  3. Fogel EL, Sherman S, Devereaux BM, Lehman GA. Therapeutic biliary endoscopy. Endoscopy. 2001;33:31–8.

    Article  CAS  PubMed  Google Scholar 

  4. Baron TH, Petersen BT, Mergener K, et al. Quality indicators for endoscopic retrograde cholangiopancreatography. Gastrointest Endosc. 2006;63:S29–34.

    Article  PubMed  Google Scholar 

  5. Beissert M, Wittenberg G, Sandstede J, et al. Metallic stents and plastic endoprostheses in percutaneous treatment of biliary obstruction. Z Gastroenterol. 2002;40:503–10.

    Article  CAS  PubMed  Google Scholar 

  6. Kama NA, Coskun T, Yuksek YN, Yazgan A. Factors affecting post-operative mortality in malignant biliary tract obstruction. Hepato-Gastroenterology. 1999;46:103–7.

    CAS  PubMed  Google Scholar 

  7. Weber A, Gaa J, Rosca B, et al. Complications of percutaneous transhepatic biliary drainage in patients with dilated and nondilated intrahepatic bile ducts. Eur J Radiol. 2009;72:412–7.

    Article  PubMed  Google Scholar 

  8. Artifon EL, Sakai P, Cunha JE, et al. Surgery or endoscopy for palliation of biliary obstruction due to metastatic pancreatic cancer. Am J Gastroenterol. 2006;101:2031–7.

    Article  PubMed  Google Scholar 

  9. Wiersema MJ, Sandusky D, Carr R, Wiersema LM, Erdel WC, Frederick PK. Endosonography-guided cholangiopancreatography. Gastrointest Endosc. 1996;43:102–6.

    Article  CAS  PubMed  Google Scholar 

  10. Giovannini M, Moutardier V, Pesenti C, Bories E, Lelong B, Delpero JR. Endoscopic ultrasound-guided bilioduodenal anastomosis: a new technique for biliary drainage. Endoscopy. 2001;33:898–900.

    Article  CAS  PubMed  Google Scholar 

  11. Itoi T, Sofuni A, Itokawa F, et al. Endoscopic ultrasonography-guided biliary drainage. J Hepato-Biliary-Pancreat Sci. 2010;17:611–6.

    Article  Google Scholar 

  12. Kahaleh M, Hernandez AJ, Tokar J, Adams RB, Shami VM, Yeaton P. Interventional EUS-guided cholangiography: evaluation of a technique in evolution. Gastrointest Endosc. 2006;64:52–9.

    Article  PubMed  Google Scholar 

  13. Bories E, Pesenti C, Caillol F, Lopes C, Giovannini M. Transgastric endoscopic ultrasonography-guided biliary drainage: results of a pilot study. Endoscopy. 2007;39:287–91.

    Article  CAS  PubMed  Google Scholar 

  14. Kim YS, Gupta K, Mallery S, Li R, Kinney T, Freeman ML. Endoscopic ultrasound rendezvous for bile duct access using a transduodenal approach: cumulative experience at a single center. A case series. Endoscopy. 2010;42:496–502.

    Article  CAS  PubMed  Google Scholar 

  15. Hanada K, Iiboshi T, Ishii Y. Endoscopic ultrasound-guided choledochoduodenostomy for palliative biliary drainage in cases with inoperable pancreas head carcinoma. Dig Endosc Off Japan Gastroenterol Endosc Soc. 2009;21 Suppl 1:S75–8.

    Google Scholar 

  16. Maranki J, Hernandez AJ, Arslan B, et al. Interventional endoscopic ultrasound-guided cholangiography: long-term experience of an emerging alternative to percutaneous transhepatic cholangiography. Endoscopy. 2009;41:532–8.

    Article  CAS  PubMed  Google Scholar 

  17. Kahaleh M, Artifon EL, Perez-Miranda M, et al. Endoscopic ultrasonography guided biliary drainage: summary of consortium meeting, May 7th, 2011, Chicago. World J Gastroenterol: WJG. 2013;19:1372–9. Good review paper discussing various options of EUS guided biliary drainage.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Fabbri C, Luigiano C, Lisotti A, et al. Endoscopic ultrasound-guided treatments: are we getting evidence based—a systematic review. World J Gastroenterol: WJG. 2014;20:8424–48.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Mallery S, Matlock J, Freeman ML. EUS-guided rendezvous drainage of obstructed biliary and pancreatic ducts: report of 6 cases. Gastrointest Endosc. 2004;59:100–7.

    Article  PubMed  Google Scholar 

  20. Sarkaria S, Lee HS, Gaidhane M, Kahaleh M. Advances in endoscopic ultrasound-guided biliary drainage: a comprehensive review. Gut Liver. 2013;7:129–36.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Yamao K, Hara K, Mizuno N, et al. EUS-guided biliary drainage. Gut Liver. 2010;4 Suppl 1:S67–75.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Kahaleh M, Wang P, Shami VM, Tokar J, Yeaton P. EUS-guided transhepatic cholangiography: report of 6 cases. Gastrointest Endosc. 2005;61:307–13.

    Article  PubMed  Google Scholar 

  23. Kahaleh M, Yoshida C, Kane L, Yeaton P. Interventional EUS cholangiography: a report of five cases. Gastrointest Endosc. 2004;60:138–42.

    Article  PubMed  Google Scholar 

  24. Tarantino I, Barresi L, Repici A, Traina M. EUS-guided biliary drainage: a case series. Endoscopy. 2008;40:336–9.

    Article  CAS  PubMed  Google Scholar 

  25. Shah JN, Marson F, Weilert F, et al. Single-operator, single-session EUS-guided anterograde cholangiopancreatography in failed ERCP or inaccessible papilla. Gastrointest Endosc. 2012;75:56–64.

    Article  PubMed  Google Scholar 

  26. Iwashita T, Lee JG. Endoscopic ultrasonography-guided biliary drainage: rendezvous technique. Gastrointest Endosc Clin N Am. 2012;22:249–58.

    Article  PubMed  Google Scholar 

  27. Dhir V, Bhandari S, Bapat M, Maydeo A. Comparison of EUS-guided rendezvous and precut papillotomy techniques for biliary access (with videos). Gastrointest Endosc. 2012;75:354–9. Comparative study on EUS-guided rendezvous vs ERCP and precut for biliary access.

    Article  PubMed  Google Scholar 

  28. Kawakubo K, Isayama H, Sasahira N, et al. Clinical utility of an endoscopic ultrasound-guided rendezvous technique via various approach routes. Surg Endosc. 2013;27:3437–43.

    Article  PubMed  Google Scholar 

  29. do Park H, Jeong SU, Lee BU, et al. Prospective evaluation of a treatment algorithm with enhanced guidewire manipulation protocol for EUS-guided biliary drainage after failed ERCP (with video). Gastrointest Endosc. 2013;78:91–101. Larger scale study on a algorithm for EUS-guided biliary drainage under various conditions.

    Article  Google Scholar 

  30. Khashab MA, Valeshabad AK, Modayil R, et al. EUS-guided biliary drainage by using a standardized approach for malignant biliary obstruction: rendezvous versus direct transluminal techniques (with videos). Gastrointest Endosc. 2013;78:734–41. Large scale study comparing rendezvous and transluminal techniques of EUS biliary drainage.

    Article  PubMed  Google Scholar 

  31. Kahaleh M, Shami VM, Conaway MR, et al. Endoscopic ultrasound drainage of pancreatic pseudocyst: a prospective comparison with conventional endoscopic drainage. Endoscopy. 2006;38:355–9.

    Article  CAS  PubMed  Google Scholar 

  32. Dhir V, Bhandari S, Bapat M, Joshi N, Vivekanandarajah S, Maydeo A. Comparison of transhepatic and extrahepatic routes for EUS-guided rendezvous procedure for distal CBD obstruction. U Eur Gastroenterol J. 2013;1:103–8.

    Article  Google Scholar 

  33. Larkin CJ, Huibregtse K. Precut sphincterotomy: indications, pitfalls, and complications. Curr Gastroenterol Rep. 2001;3:147–53.

    Article  CAS  PubMed  Google Scholar 

  34. Barthet M, Lesavre N, Desjeux A, et al. Complications of endoscopic sphincterotomy: results from a single tertiary referral center. Endoscopy. 2002;34:991–7.

    Article  CAS  PubMed  Google Scholar 

  35. Artifon EL, Ferreira FC, Otoch JP, Rasslan S, Itoi T, Perez-Miranda M. EUS-guided biliary drainage: a review article. JOP: J Pancreas. 2012;13:7–17.

    Google Scholar 

  36. Brauer BC, Chen YK, Fukami N, Shah RJ. Single-operator EUS-guided cholangiopancreatography for difficult pancreaticobiliary access (with video). Gastrointest Endosc. 2009;70:471–9.

    Article  PubMed  Google Scholar 

  37. Komaki T, Kitano M, Sakamoto H, Kudo M. Endoscopic ultrasonography-guided biliary drainage: evaluation of a choledochoduodenostomy technique. PancreatolOff J Int Assoc Pancreatol. 2011;11 Suppl 2:47–51.

    Google Scholar 

  38. Perez-Miranda M, De la Serna HC, Gil-Simon P, Hernandez V, Diez-Redondo P, Fernandez-Salazar L. EUS-guided choledochoduodenostomy with lumen-apposing metal stent after failed rendezvous in synchronous malignant biliary and gastric outlet obstruction (with video). Gastrointest Endosc. 2014;80:342. discussion 3–4.

    Article  PubMed  Google Scholar 

  39. Artifon EL, Okawa L, Takada J, Gupta K, Moura EG, Sakai P. EUS-guided choledochoantrostomy: an alternative for biliary drainage in unresectable pancreatic cancer with duodenal invasion. Gastrointest Endosc. 2011;73:1317–20.

    Article  PubMed  Google Scholar 

  40. Talreja JP, Shami VM, Ku J, Morris TD, Ellen K, Kahaleh M. Transenteric drainage of pancreatic-fluid collections with fully covered self-expanding metallic stents (with video). Gastrointest Endosc. 2008;68:1199–203.

    Article  PubMed  Google Scholar 

  41. Burmester E, Niehaus J, Leineweber T, Huetteroth T. EUS-cholangio-drainage of the bile duct: report of 4 cases. Gastrointest Endosc. 2003;57:246–51.

    Article  PubMed  Google Scholar 

  42. Puspok A, Lomoschitz F, Dejaco C, Hejna M, Sautner T, Gangl A. Endoscopic ultrasound guided therapy of benign and malignant biliary obstruction: a case series. Am J Gastroenterol. 2005;100:1743–7.

    Article  PubMed  Google Scholar 

  43. Yamao K, Sawaki A, Takahashi K, Imaoka H, Ashida R, Mizuno N. EUS-guided choledochoduodenostomy for palliative biliary drainage in case of papillary obstruction: report of 2 cases. Gastrointest Endosc. 2006;64:663–7.

    Article  PubMed  Google Scholar 

  44. Fujita N, Noda Y, Kobayashi G, et al. Histological changes at an endosonography-guided biliary drainage site: a case report. World J Gastroenterol: WJG. 2007;13:5512–5.

    Article  PubMed Central  PubMed  Google Scholar 

  45. Ang TL, Teo EK, Fock KM. EUS-guided transduodenal biliary drainage in unresectable pancreatic cancer with obstructive jaundice. JOP: JPancreas. 2007;8:438–43.

    Google Scholar 

  46. Yamao K, Bhatia V, Mizuno N, et al. EUS-guided choledochoduodenostomy for palliative biliary drainage in patients with malignant biliary obstruction: results of long-term follow-up. Endoscopy. 2008;40:340–2.

    Article  CAS  PubMed  Google Scholar 

  47. Itoi T, Itokawa F, Sofuni A, et al. Endoscopic ultrasound-guided choledochoduodenostomy in patients with failed endoscopic retrograde cholangiopancreatography. World J Gastroenterol: WJG. 2008;14:6078–82.

    Article  PubMed Central  PubMed  Google Scholar 

  48. Horaguchi J, Fujita N, Noda Y, et al. Endosonography-guided biliary drainage in cases with difficult transpapillary endoscopic biliary drainage. Dig Endosc: Off J Japan Gastroenterol Endosc Soc. 2009;21:239–44.

    Article  Google Scholar 

  49. do Park H, Koo JE, Oh J, et al. EUS-guided biliary drainage with one-step placement of a fully covered metal stent for malignant biliary obstruction: a prospective feasibility study. Am J Gastroenterol. 2009;104:2168–74.

    Article  Google Scholar 

  50. Iwamuro M, Kawamoto H, Harada R, et al. Combined duodenal stent placement and endoscopic ultrasonography-guided biliary drainage for malignant duodenal obstruction with biliary stricture. Dig Endosc: Off J Japan Gastroenterol Endosc Soc. 2010;22:236–40.

    Article  Google Scholar 

  51. Siddiqui AA, Sreenarasimhaiah J, Lara LF, Harford W, Lee C, Eloubeidi MA. Endoscopic ultrasound-guided transduodenal placement of a fully covered metal stent for palliative biliary drainage in patients with malignant biliary obstruction. Surg Endosc. 2011;25:549–55.

    Article  PubMed  Google Scholar 

  52. Belletrutti PJ, DiMaio CJ, Gerdes H, Schattner MA. Endoscopic ultrasound guided biliary drainage in patients with unapproachable ampullae due to malignant duodenal obstruction. J Gastrointest Cancer. 2011;42:137–42.

    Article  PubMed  Google Scholar 

  53. Hara K, Yamao K, Mizuno N, et al. Interventional endoscopic ultrasonography for pancreatic cancer. World J Clin Oncol. 2011;2:108–14.

    Article  PubMed Central  PubMed  Google Scholar 

  54. Ramirez-Luna MA, Tellez-Avila FI, Giovannini M, Valdovinos-Andraca F, Guerrero-Hernandez I, Herrera-Esquivel J. Endoscopic ultrasound-guided biliodigestive drainage is a good alternative in patients with unresectable cancer. Endoscopy. 2011;43:826–30.

    Article  CAS  PubMed  Google Scholar 

  55. do Park H, Jang JW, Lee SS, Seo DW, Lee SK, Kim MH. EUS-guided biliary drainage with transluminal stenting after failed ERCP: predictors of adverse events and long-term results. Gastrointest Endosc. 2011;74:1276–84.

    Article  Google Scholar 

  56. Fabbri C, Luigiano C, Fuccio L, et al. EUS-guided biliary drainage with placement of a new partially covered biliary stent for palliation of malignant biliary obstruction: a case series. Endoscopy. 2011;43:438–41.

    Article  CAS  PubMed  Google Scholar 

  57. Kawakubo K, Isayama H, Nakai Y, et al. Simultaneous duodenal metal stent placement and EUS-guided choledochoduodenostomy for unresectable pancreatic cancer. Gut Liver. 2012;6:399–402.

    Article  PubMed Central  PubMed  Google Scholar 

  58. Katanuma A, Maguchi H, Osanai M, Takahashi K. Endoscopic ultrasound-guided biliary drainage performed for refractory bile duct stenosis due to chronic pancreatitis: a case report. Dig Endosc: Off J Japan Gastroenterol Endosc Soc. 2012;24 Suppl 1:34–7.

    Article  Google Scholar 

  59. Attasaranya S, Netinasunton N, Jongboonyanuparp T, et al. The spectrum of endoscopic ultrasound intervention in biliary diseases: a single center’s experience in 31 cases. Gastroenterol Res Pract. 2012;2012:680753.

    Article  PubMed Central  PubMed  Google Scholar 

  60. Artifon EL, Aparicio D, Paione JB, et al. Biliary drainage in patients with unresectable, malignant obstruction where ERCP fails: endoscopic ultrasonography-guided choledochoduodenostomy versus percutaneous drainage. J Clin Gastroenterol. 2012;46:768–74. Small randomized study on an important question of EUS vs percutaneous biliary drainage.

    Article  PubMed  Google Scholar 

  61. Kim TH, Kim SH, Oh HJ, Sohn YW, Lee SO. Endoscopic ultrasound-guided biliary drainage with placement of a fully covered metal stent for malignant biliary obstruction. World J Gastroenterol: WJG. 2012;18:2526–32.

    Article  PubMed Central  PubMed  Google Scholar 

  62. Song TJ, Hyun YS, Lee SS, et al. Endoscopic ultrasound-guided choledochoduodenostomies with fully covered self-expandable metallic stents. World J Gastroenterol: WJG. 2012;18:4435–40.

    Article  PubMed Central  PubMed  Google Scholar 

  63. Vila JJ, Perez-Miranda M, Vazquez-Sequeiros E, et al. Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey. Gastrointest Endosc. 2012;76:1133–41.

    Article  PubMed  Google Scholar 

  64. Tonozuka R, Itoi T, Sofuni A, Itokawa F, Moriyasu F. Endoscopic double stenting for the treatment of malignant biliary and duodenal obstruction due to pancreatic cancer. Dig Endosc: Off J Japan Gastroenterol Endosc Soc. 2013;25 Suppl 2:100–8.

    Article  Google Scholar 

  65. Hara K, Yamao K, Hijioka S, et al. Prospective clinical study of endoscopic ultrasound-guided choledochoduodenostomy with direct metallic stent placement using a forward-viewing echoendoscope. Endoscopy. 2013;45:392–6.

    Article  CAS  PubMed  Google Scholar 

  66. Kawakubo K, Isayama H, Kato H, et al. Multicenter retrospective study of endoscopic ultrasound-guided biliary drainage for malignant biliary obstruction in Japan. J Hepato-Biliary-Pancreat Sci. 2014;21:328–34.

    Article  Google Scholar 

  67. Itoi T, Isayama H, Sofuni A, et al. Stent selection and tips on placement technique of EUS-guided biliary drainage: transduodenal and transgastric stenting. J Hepato-Biliary-Pancreat Sci. 2011;18:664–72.

    Article  Google Scholar 

  68. Song TJ, Lee SS, do Park H, Seo DW, Lee SK, Kim MH. Preliminary report on a new hybrid metal stent for EUS-guided biliary drainage (with videos). Gastrointest Endosc. 2014;80:707–11.

    Article  PubMed  Google Scholar 

  69. Wilson JA, Hoffman B, Hawes RH, Romagnuolo J. EUS in patients with surgically altered upper GI anatomy. Gastrointest Endosc. 2010;72:947–53.

    Article  PubMed  Google Scholar 

  70. Giovannini M, Dotti M, Bories E, et al. Hepaticogastrostomy by echo-endoscopy as a palliative treatment in a patient with metastatic biliary obstruction. Endoscopy. 2003;35:1076–8.

    Article  CAS  PubMed  Google Scholar 

  71. Artifon EL, Chaves DM, Ishioka S, Souza TF, Matuguma SE, Sakai P. Echoguided hepatico-gastrostomy: a case report. Clinics. 2007;62:799–802.

    Article  PubMed  Google Scholar 

  72. Will U, Meyer F, Schmitt W, Dollhopf M. Endoscopic ultrasound-guided transesophageal cholangiodrainage and consecutive endoscopic transhepatic Wallstent insertion into a jejunal stenosis. Scand J Gastroenterol. 2007;42:412–5.

    Article  PubMed  Google Scholar 

  73. do Park H, Song TJ, Eum J, et al. EUS-guided hepaticogastrostomy with a fully covered metal stent as the biliary diversion technique for an occluded biliary metal stent after a failed ERCP (with videos). Gastrointest Endosc. 2010;71:413–9.

    Article  Google Scholar 

  74. Gupta K, Perez-Miranda M, Kahaleh M, et al. Endoscopic ultrasound-assisted bile duct access and drainage: multicenter, long-term analysis of approach, outcomes, and complications of a technique in evolution. J Clin Gastroenterol. 2014;48:80–7.

    Article  PubMed  Google Scholar 

  75. Ang TL, Ng VW, Fock KM, Teo EK, Chong CK. Diagnosis of a metastatic phyllodes tumor of the pancreas using EUS-FNA. JOP: J Pancreas. 2007;8:35–8.

    Google Scholar 

  76. Hara K, Yamao K, Niwa Y, et al. Prospective clinical study of EUS-guided choledochoduodenostomy for malignant lower biliary tract obstruction. Am J Gastroenterol. 2011;106:1239–45.

    Article  PubMed  Google Scholar 

  77. Iwamuro M, Okada H, Kawahara Y, et al. Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement. World J Gastroenterol: WJG. 2010;16:4661–9.

    Article  PubMed Central  PubMed  Google Scholar 

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Shannon Melissa Chan and Anthony Yuen Bun Teoh declare that they have no conflict of interest.

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  1. Department of Surgery, The Chinese University of Hong Kong, Hong Kong, SAR, China

    Shannon Melissa Chan M.B.Ch.B., F.R.C.S.Ed. & Anthony Yuen Bun Teoh M.B.Ch.B., F.R.C.S.Ed., F.H.K.A.M.

  2. Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

    Anthony Yuen Bun Teoh M.B.Ch.B., F.R.C.S.Ed., F.H.K.A.M.

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Chan, S.M., Teoh, A.Y.B. Endoscopic Ultrasound-Guided Biliary Drainage: a Review. Curr Treat Options Gastro 13, 171–184 (2015). https://doi.org/10.1007/s11938-015-0047-x

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