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Characterizing Indeterminate Renal Masses with Molecular Imaging: the Role of 99mTc-MIBI SPECT/CT

  • New Imaging Techniques (S Rais-Bahrami and A George, Section Editors)
  • Published:
Current Urology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The majority of enhancing renal masses cannot be characterized through imaging as malignant or benign; however, such characterization could save patients from unnecessary surgery and/or biopsy and associated morbidity. Herein, we review the recent literature on the emerging use of 99mTc-MIBI SPECT/CT in preoperative differentiation of enhancing renal masses.

Recent Findings

Recent reports have shown that 99mTc-MIBI SPECT/CT imaging can differentiate mitochondrial-rich, benign, or indolent renal masses from renal cell carcinoma. These studies demonstrate good correlation between a positive 99mTc-MIBI SPECT/CT scan and a pathologically proven diagnosis of renal oncocytoma and hybrid oncocytic/chromophobe tumor. In addition, there is excellent correlation between a negative scan and a diagnosis of clear cell subtype of renal cell carcinoma.

Summary

Preoperative 99mTc-MIBI SPECT/CT offers a non-invasive method for differentiating renal lesions with low aggressiveness from other RCCs, in particular, clear cell renal cell carcinoma.

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Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Authors and Affiliations

  1. Department of Radiology, University of Alabama at Birmingham School of Medicine, 619 19th Street South, JT N325, Birmingham, AL, 35249-6830, USA

    Andrew M. Reynolds & Kristin Kelly Porter

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  1. Andrew M. Reynolds
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  2. Kristin Kelly Porter
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Correspondence to Kristin Kelly Porter.

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Conflict of Interest

Andrew M. Reynolds and Kristin Kelly Porter each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on New Imaging Techniques

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Reynolds, A.M., Porter, K.K. Characterizing Indeterminate Renal Masses with Molecular Imaging: the Role of 99mTc-MIBI SPECT/CT. Curr Urol Rep 18, 86 (2017). https://doi.org/10.1007/s11934-017-0737-0

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  • DOI: https://doi.org/10.1007/s11934-017-0737-0

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