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Growth factors in benign prostatic hyperplasia: Basic science implications

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Abstract

Benign prostatic hyperplasia (BPH) is the most common proliferative disease of the prostate of men in the United States. The histopathology of BPH strongly implicates local paracrine and autocrine growth factors and inflammatory cytokines in its pathogenesis. A complex milieu of growth-regulatory proteins includes members of the fibroblast, insulin-like, and transforming growth factor families. It appears that these proteins and downstream effector molecules, in addition to a variety of interleukins, are overexpressed in BPH and, working together, create a landscape of increased stromal and epithelial growth and mesenchymal transdifferentiation that leads to disease progression. Inflammation, commonly present in BPH, may contribute to tissue injury, and cytokines produced by inflammatory cells may serve to drive local growth factor production and angiogenesis in the tissues as a “wound healing” response. As we begin to unravel the precise mechanisms involved, new treatments for BPH aimed at these interacting pathways may emerge.

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Authors and Affiliations

  1. Department of Pathology, University of Colorado DHSC, Mail Stop 8104, UCHSC at Fitzsimons, Building RC-1 North Tower, Room 5128, 12800 East 19th Avenue, PO Box 6511, Aurora, CO, 80045, USA

    M. Scott Lucia

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  1. M. Scott Lucia
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  2. James R. Lambert
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Correspondence to M. Scott Lucia.

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Scott Lucia, M., Lambert, J.R. Growth factors in benign prostatic hyperplasia: Basic science implications. Curr Urol Rep 9, 272–278 (2008). https://doi.org/10.1007/s11934-008-0048-6

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  • DOI: https://doi.org/10.1007/s11934-008-0048-6

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