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Bone Homeostasis and Repair: Forced Into Shape

  • Osteoarthritis (MB Goldring, Section Editor)
  • Published:
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Abstract

Mechanical loading is a potent anabolic regulator of bone mass, and the first line of defense for bone loss is weight-bearing exercise. Likewise, protected weight bearing is the first prescribed physical therapy following orthopedic reconstructive surgery. In both cases, enhancement of new bone formation is the goal. Our understanding of the physical cues, mechanisms of force sensation, and the subsequent cellular response will help identify novel physical and therapeutic treatments for age- and disuse-related bone loss, delayed- and nonunion fractures, and significant bony defects. This review highlights important new insights into the principles and mechanisms governing mechanical adaptation of the skeleton during homeostasis and repair and ends with a summary of clinical implications stemming from our current understanding of how bone adapts to biophysical force.

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Authors and Affiliations

  1. Department of Mechanical and Aerospace Engineering, New York University Polytechnic School of Engineering, New York, NY, USA

    Alesha B. Castillo

  2. Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY, USA

    Alesha B. Castillo & Philipp Leucht

  3. Veterans Affairs New York Harbor Healthcare System, New York, NY, USA

    Alesha B. Castillo

  4. Department of Cell Biology, New York University School of Medicine, New York, NY, USA

    Philipp Leucht

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  1. Alesha B. Castillo
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  2. Philipp Leucht
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Correspondence to Alesha B. Castillo.

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Castillo, A.B., Leucht, P. Bone Homeostasis and Repair: Forced Into Shape. Curr Rheumatol Rep 17, 58 (2015). https://doi.org/10.1007/s11926-015-0537-9

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