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Treg Cells in Rheumatoid Arthritis: An Update

  • RHEUMATOID ARTHRITIS (LW MORELAND, SECTION EDITOR)
  • Published:
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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses to autoantigens. Regulatory CD4+ T-cells (Tregs) underpin one of the key mechanisms of self-tolerance and are a major focus of study in RA and other autoimmune diseases. In order to design new and improved therapies to reinstate self-tolerance, and perhaps cure disease, we need to understand the complex mechanism of action of Tregs. This review addresses recent findings in the field of Tregs in RA, with particular focus on identification of potential defects in Treg-mediated self-tolerance mechanisms present in RA patients, as well as how Tregs interact with other cells in the inflamed joints. As antigen-specific Tregs are a potential route for the reinstatement of immune tolerance, we also discuss new strategies currently being investigated which expand or induce de novo generation of Tregs.

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The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

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Faye A. H. Cooles declares that she has no conflict of interest.

John D. Isaacs declares that he has no conflict of interest.

Amy E. Anderson declares that she has no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Newcastle NIHR Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, UK

    Faye A. H. Cooles, John D. Isaacs & Amy E. Anderson

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  1. Faye A. H. Cooles
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Correspondence to John D. Isaacs.

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This article is part of the Topical Collection on Rheumatoid Arthritis

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Cooles, F.A.H., Isaacs, J.D. & Anderson, A.E. Treg Cells in Rheumatoid Arthritis: An Update. Curr Rheumatol Rep 15, 352 (2013). https://doi.org/10.1007/s11926-013-0352-0

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