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Recent advances in structural and functional brain imaging studies of attention-deficit/hyperactivity disorder

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Abstract

The field of neuroimaging of attention-deficit/hyperactivity disorder (ADHD) is now 30 years old. This brief selective review highlights the increasing sophistication of recent structural and functional neuroimaging studies of ADHD. In volumetric studies, investigators are examining extra-frontal, as well as frontal-striatal circuits and beginning to differentiate the potential effects of medication exposure. Functional MRI studies are focusing on familial/genetic influences and enrolling medication naïve, as well as medicated children with ADHD. A promising trend is the application of resting state approaches to mapping functional connectivity, which provides unexpectedly detailed information about interregional relationships while bypassing potentially confounding issues related to task performance. These developments allow us to conclude that neuroimaging studies of ADHD will increasingly inform our understanding of the neuronal substrates of ADHD.

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References and Recommended Reading

  1. Krain AL, Castellanos FX: Brain development and ADHD. Clin Psychol Rev 2006, 26:433–444.

    PubMed  Google Scholar 

  2. Valera EM, Faraone SV, Murray KE, Seidman LJ: Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol Psychiatry 2007, 61:1361–1369.

    Article  PubMed  Google Scholar 

  3. Plessen KJ, Bansal R, Zhu H, et al.: Hippocampus and amygdala morphology in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 2006, 63:795–807.

    Article  PubMed  Google Scholar 

  4. Wellington TM, Semrud-Clikeman M, Gregory AL, et al.: Magnetic resonance imaging volumetric analysis of the putamen in children with ADHD: combined type versus control. J Atten Disord 2006, 10:171–180.

    Article  PubMed  Google Scholar 

  5. Arndt S, Cohen G, Alliger RJ, et al.: Problems with ratio and proportion measures of imaged cerebral structures. Psychiatry Res 1991, 40:79–89.

    Article  PubMed  CAS  Google Scholar 

  6. McAlonan GM, Cheung V, Cheung C, et al.: Mapping brain structure in attention deficit-hyperactivity disorder: a voxel-based MRI study of regional grey and white matter volume. Psychiatry Res 2007, 154:171–180.

    Article  PubMed  Google Scholar 

  7. Pliszka SR, Lancaster J, Liotti M, Semrud-Clikeman M: Volumetric MRI differences in treatment-naive vs chronically treated children with ADHD. Neurology 2006, 67:1023–1027.

    Article  PubMed  Google Scholar 

  8. Shaw P, Lerch J, Greenstein D, et al.: Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 2006, 63:540–549.

    Article  PubMed  Google Scholar 

  9. Makris N, Biederman J, Valera EM, et al.: Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder. Cereb Cortex 2007, 17:1364–1375.

    Article  PubMed  Google Scholar 

  10. Seidman LJ, Valera EM, Makris N, et al.: Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging. Biol Psychiatry 2006, 60:1071–1080.

    Article  PubMed  Google Scholar 

  11. van’t Ent D, Lehn H, Derks EM, et al.: A structural MRI study in monozygotic twins concordant or disordant for attention/hyperactivity problems: evidence for genetic and environmental heterogeneity in the developing brain. Neuroimage 2007, 35:1004–1020.

    Article  Google Scholar 

  12. Dickstein SG, Bannon K, Castellanos FX, Milham MP: The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis. J Child Psych Psychiatry 2006, 47:1051–1062.

    Article  Google Scholar 

  13. Turkeltaub PE, Eden GF, Jones KM, Zeffiro TA: Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage 2002, 16:765–780.

    Article  PubMed  Google Scholar 

  14. Silk T, Vance A, Rinehart N, et al.: Fronto-parietal activation in attention-deficit hyperactivity disorder, combined type: functional magnetic resonance imaging study. Br J Psychiatry 2005, 187:282–283.

    Article  PubMed  CAS  Google Scholar 

  15. Vance A, Silk TJ, Casey M, et al.: Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study. Mol Psychiatry 2007 [Epub ahead of print].

  16. Westerberg H, Hirvikoski T, Forssberg H, Klingberg T: Visuo-spatial working memory span: a sensitive measure of cognitive deficits in children with ADHD. Child Neuropsychol 2004, 10:155–161.

    Article  PubMed  Google Scholar 

  17. Rubia K, Smith AB, Brammer MJ, Taylor E: Temporal lobe dysfunction in medication-naive boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variability. Biol Psychiatry 2007 [Epub ahead of print].

  18. Smith AB, Taylor E, Brammer M, et al.: Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorder. Am J Psychiatry 2006, 163:1044–1051.

    Article  PubMed  Google Scholar 

  19. Scheres A, Milham MP, Knutson B, Castellanos FX: Ventral striatal hyporesponsiveness during reward anticipation in attention deficit/hyperactivity disorder. Biol Psychiatry 2007, 61:720–724.

    Article  PubMed  Google Scholar 

  20. Durston S, David MC, Mulder M, et al.: Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorder. J Child Psychol Psychiatry 2007, In press.

  21. Hale TS, Bookheimer S, McGough JJ, et al.: Atypical brain activation during simple and complex levels of processing in adult ADHD: an fMRI study. J Atten Disord 2007 [Epub ahead of print].

  22. Konrad K, Neufang S, Hanisch C, et al.: Dysfunctional attentional networks in children with attention deficit/hyperactivity disorder: evidence from an event-related functional magnetic resonance imaging study. Biol Psychiatry 2006, 59:643–651.

    Article  PubMed  Google Scholar 

  23. Pliszka SR, Glahn DC, Semrud-Clikeman M, et al.: Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment. Am J Psychiatry 2006, 163:1052–1060.

    Article  PubMed  Google Scholar 

  24. O’Keeffe FM, Dockree PM, Moloney P, et al.: Characterising error-awareness of attentional lapses and inhibitory control failures in patients with traumatic brain injury. Exp Brain Res 2007, 180:59–67.

    Article  PubMed  CAS  Google Scholar 

  25. Durston S, Mulder M, Casey BJ, et al.: Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder. Biol Psychiatry 2006, 60:1062–1070.

    Article  PubMed  CAS  Google Scholar 

  26. Castellanos FX, Tannock R: Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 2002, 3:617–628.

    PubMed  CAS  Google Scholar 

  27. Simmonds DJ, Fotedar SG, Suskauer SJ, et al.: Functional brain correlates of response time variability in children. Neuropsychologia 2007, 45:2147–2157.

    Article  PubMed  Google Scholar 

  28. Bellgrove MA, Hester R, Garavan H: The functional neuroanatomical correlates of response variability: evidence from a response inhibition task. Neuropsychologia 2004, 42:1910–1916.

    Article  PubMed  Google Scholar 

  29. Buckner RL, Vincent JL: Unrest at rest: the importance of default activity and spontaneous network correlations. Neuroimage 2007 [Epub ahead of print].

  30. Raichle ME, MacLeod AM, Snyder AZ, et al.: A default mode of brain function. Proc Natl Acad Sci U S A 2001, 98:676–682.

    Article  PubMed  CAS  Google Scholar 

  31. Cao Q, Zang Y, Sun L, et al.: Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study. Neuroreport 2006, 17:1033–1036.

    Article  PubMed  Google Scholar 

  32. Tian L, Jiang T, Wang Y, et al.: Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder. Neurosci Lett 2006, 400:39–43.

    Article  PubMed  CAS  Google Scholar 

  33. Zang YF, He Y, Zhu CZ, et al.: Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev 2007, 29:83–91.

    Article  PubMed  Google Scholar 

  34. Zhu CZ, Zang YF, Liang M, et al.: Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2005, 8:468–475.

    PubMed  CAS  Google Scholar 

  35. Weissman DH, Roberts KC, Visscher KM, Woldorff MG: The neural bases of momentary lapses in attention. Nat Neurosci 2006, 9:971–978.

    Article  PubMed  CAS  Google Scholar 

  36. Sonuga-Barke EJ, Castellanos FX: Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neurosci Biobehav Rev 2007 [Epub ahead of print].

  37. Castellanos FX, Margulies DS, Kelly AM, et al.: Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol Psychiatry 2007, In press.

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Authors and Affiliations

  1. Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY, 10016, USA

    F. Xavier Castellanos

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  1. A. M. Clare Kelly
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  2. Daniel S. Margulies
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  3. F. Xavier Castellanos
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Correspondence to F. Xavier Castellanos.

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Kelly, A.M.C., Margulies, D.S. & Castellanos, F.X. Recent advances in structural and functional brain imaging studies of attention-deficit/hyperactivity disorder. Curr Psychiatry Rep 9, 401–407 (2007). https://doi.org/10.1007/s11920-007-0052-4

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  • DOI: https://doi.org/10.1007/s11920-007-0052-4

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