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Bone Mineral Density Deficits and Fractures in Survivors of Childhood Cancer

  • Osteoporosis and Cancer (P Taxel, Section Editor)
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Abstract

Although substantial increases in survival rates among children diagnosed with cancer have been observed in recent decades, survivors are at risk of developing therapy-related chronic health conditions. Among children and adolescents treated for cancer, acquisition of peak bone mass may be compromised by cancer therapies, nutritional deficiencies, and reduced physical activity. Accordingly, failure to accrue optimal bone mass during childhood may place survivors at increased risk for deficits in bone density and fracture in later life. Current recommendations for the treatment of bone density decrements among cancer survivors include dietary counseling and supplementation to ensure adequate calcium and vitamin D intake. Few strategies exist to prevent or treat bone loss. Moving forward, studies characterizing the trajectory of changes in bone density over time will facilitate the development of interventions and novel therapies aimed at minimizing bone loss among survivors of childhood cancer.

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C.L. Wilson declares that she has no conflicts of interest. K.K. Ness declares that she has no conflicts of interest.

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  1. Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, MS-735, Memphis, TN, 38105, USA

    Carmen L. Wilson & Kirsten K. Ness

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Wilson, C.L., Ness, K.K. Bone Mineral Density Deficits and Fractures in Survivors of Childhood Cancer. Curr Osteoporos Rep 11, 329–337 (2013). https://doi.org/10.1007/s11914-013-0165-0

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