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Radiation-Induced Cardiovascular Disease: Mechanisms, Prevention, and Treatment

  • Cardio-oncology (JN Upshaw, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Despite the advancements of modern radiotherapy, radiation-induced cardiovascular disease (RICVD) remains a common cause of morbidity and mortality among cancer survivors.

Recent Findings

Proposed pathogenetic mechanisms of RICVD include endothelial cell damage with accelerated atherosclerosis, pro-thrombotic alterations in the coagulation pathway as well as inflammation and fibrosis of the myocardial, pericardial, valvular, and conduction tissues. Prevention of RICVD can be achieved by minimizing the exposure of the cardiovascular system to radiation, by treatment of underlying cardiovascular risk factors and cardiovascular disease, and possibly by prophylactic pharmacotherapy post exposure.

Summary

Herein we summarize current knowledge on the mechanisms underlying the pathogenesis of RICVD and propose prevention and treatment strategies.

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Authors and Affiliations

  1. Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Efstratios Koutroumpakis, Anita Deswal, Syed Wamique Yusuf, Jun-ichi Abe, Adam S. Potter & Nicolas L. Palaskas

  2. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Kevin T. Nead

  3. Division of Cardiology, The University of Texas Medical Branch, Galveston, TX, USA

    Adam S. Potter

  4. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Zhongxing Liao & Steven H. Lin

Authors
  1. Efstratios Koutroumpakis
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  2. Anita Deswal
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  3. Syed Wamique Yusuf
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  4. Jun-ichi Abe
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  5. Kevin T. Nead
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  6. Adam S. Potter
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  7. Zhongxing Liao
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  8. Steven H. Lin
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  9. Nicolas L. Palaskas
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Corresponding author

Correspondence to Efstratios Koutroumpakis.

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Conflict of Interest

AD is supported in part by the Ting Tsung and Wei Fong Chao Distinguished Chair. KTN is a Cancer Prevention Research Institute of Texas (CPRIT) Scholar in Cancer Research. KTN is supported by CPRIT RR190077, NCI L30CA253796, and NCI K08CA263313. NLP is a Cancer Prevention Research Institute of Texas (CPRIT) Scholar and Andrew Sabin Family Foundation Fellow. NLP is supported by CPRIT RP200670 and by NIH/NCI 1P01CA261669-01. The rest of the authors declare no competing interests.

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Koutroumpakis, E., Deswal, A., Yusuf, S.W. et al. Radiation-Induced Cardiovascular Disease: Mechanisms, Prevention, and Treatment. Curr Oncol Rep 24, 543–553 (2022). https://doi.org/10.1007/s11912-022-01238-8

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  • DOI: https://doi.org/10.1007/s11912-022-01238-8

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