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Promoting Brain Repair and Regeneration After Stroke: a Plea for Cell-Based Therapies

  • Neurorehabilitation and Recovery (J Krakauer and T Kitago, Section Editors)
  • Published:
Current Neurology and Neuroscience Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

After decades of hype, cell-based therapies are emerging into the clinical arena for the purposes of promoting recovery after stroke. In this review, we discuss the most recent science behind the role of cell-based therapies in ischemic stroke and the efforts to translate these therapies into human clinical trials.

Recent Findings

Preclinical data support numerous beneficial effects of cell-based therapies in both small and large animal models of ischemic stroke. These benefits are driven by multifaceted mechanisms promoting brain repair through immunomodulation, trophic support, circuit reorganization, and cell replacement.

Summary

Cell-based therapies offer tremendous potential for improving outcomes after stroke through multimodal support of brain repair. Based on recent clinical trials, cell-based therapies appear both feasible and safe in all phases of stroke. Ongoing translational research and clinical trials will further refine these therapies and have the potential to transform the approach to stroke recovery and rehabilitation.

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  1. Department of Neurology, Johns Hopkins School of Medicine, 200 N. Wolfe Street, Suite 2158, Baltimore, MD, 21287, USA

    Ania Dabrowski, Thomas J. Robinson & Ryan J. Felling

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Ryan J. Felling reports grants from NIH/NINDS for stem cell research (K08NS097704).

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Dabrowski, A., Robinson, T.J. & Felling, R.J. Promoting Brain Repair and Regeneration After Stroke: a Plea for Cell-Based Therapies. Curr Neurol Neurosci Rep 19, 5 (2019). https://doi.org/10.1007/s11910-019-0920-4

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