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Septic Encephalopathy

  • Critical Care (S Mayer, Section Editor)
  • Published:
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Abstract

Purpose of the Review

To discuss the diagnostic approach to patients with septic encephalopathy as well as the need for specific neuro-monitoring and the perspectives on future therapeutic approaches in this setting.

Recent Findings

Most of data-concern experimental studies evaluating the pathophysiology of septic encephalopathy. A combination of neurodegenerative pathways with neurovascular injury is the cornerstone for the development of such complication and the long-term neurological sequelae among survivors.

Summary

Septic encephalopathy is a common complication in septic patients. Clinical presentation may range from mild confusion and disorientation to convulsions and deep coma. The diagnosis of septic encephalopathy is made difficult by the lack of any specific clinical and non-clinical feature, in particular among sedated patients in whom neurological examination is unreliable. In spite of the high mortality rate associated with this condition, there is no prophylactic or targeted therapy to reduce or minimize brain damage in septic patients and clinical management is limited to the treatment of the underlying infection.

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Authors and Affiliations

  1. Anaesthesia and Intensive Care, IRCCS for Oncology, San Martino Policlinico Hospital, Genova, Italy

    Chiara Robba

  2. Department of Surgical Sciences and Integrated Diagnostic, University of Genova, Genova, Italy

    Chiara Robba, Ilaria Alice Crippa & Fabio Silvio Taccone

  3. Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium

    Ilaria Alice Crippa & Fabio Silvio Taccone

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  1. Chiara Robba
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Correspondence to Fabio Silvio Taccone.

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Chiara Robba, Ilaria Alice Crippa, and Fabio Silvio Taccone each declare no potential conflicts of interest.

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Robba, C., Crippa, I.A. & Taccone, F.S. Septic Encephalopathy. Curr Neurol Neurosci Rep 18, 82 (2018). https://doi.org/10.1007/s11910-018-0895-6

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