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Arterial Stiffness in Hypertension: an Update

  • Hypertension and the Kidney (RM Carey, Section Editor)
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Abstract

Purpose of Review

To update and review novel insights into the mechanisms, measurements, and therapeutic approaches to arterial stiffness.

Recent Findings

Arterial (e.g., vascular) stiffness has been shown over time to prognosticate for cardiovascular and kidney outcomes. In this context, there has been increased interest behind the mechanisms that drive arterial stiffness beyond aging and interest in how to apply newer technologies in measurement of arterial stiffness. Pulse wave velocity has been the gold standard for measurement but industry has been innovating to improve measurement with use of single-point PWV as well as pharmacologic approaches with anti-hypertensives and oral hypoglycemic agents. Emerging data on the role of the mineralocorticoid receptor, the endothelial sodium channel (EnNaC), and uric acid in arterial stiffness are promising a number of potential therapies.

Summary

Newer techniques of measuring PWV for arterial stiffness and novel therapies may soon lead to better outcomes from hypertension complications.

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Funding

This work has received financial support by a VA Merit to Adam Whaley-Connell and a Dialysis Clinics Inc, research grant to Ravi Nistala.

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Authors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA

    Korshie Dumor, Michael Shoemaker-Moyle, Ravi Nistala & Adam Whaley-Connell

  2. Harry S. Truman VA Hospital, Columbia, MO, USA

    Ravi Nistala & Adam Whaley-Connell

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  1. Korshie Dumor
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  2. Michael Shoemaker-Moyle
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  3. Ravi Nistala
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Correspondence to Korshie Dumor.

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Dr. Shoemaker-Moyle reports grants from Dialysis Clinics Inc. and from Veterans Administration, during the conduct of the study. Dr. Nistala reports grants from Dialysis Clinics Inc. during the conduct of the study. The other authors declare no conflicts of interest relevant to this manuscript.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Hypertension and the Kidney

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Dumor, K., Shoemaker-Moyle, M., Nistala, R. et al. Arterial Stiffness in Hypertension: an Update. Curr Hypertens Rep 20, 72 (2018). https://doi.org/10.1007/s11906-018-0867-x

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