Abstract
The recent report of an infant that appears to have achieved a “functional cure” of HIV-1 following receipt of antiretroviral therapy (ART) within 30 hours of birth raises many questions: was the child infected? Was this result due to unique features of this particular infant’s immune system, the immune system of infants or the very early initiation of effective ART? In this manuscript, we discuss the pathogenesis of HIV-1 in infants, highlighting the unique features of infant immune development and how these may inform efforts to cure HIV infection. We will also compare the path to infant “cure” to cures in adults.
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Acknowledgments
This work was supported by grants from the National Institute of Health (R01 HD 39611, R01 HD 40777, R01 HD 57617, AI 100147) and the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT). Overall support for IMPAACT was provided by the National Institute of Allergy and Infectious Diseases (NIAID) (U01 AI 68632), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Institute of Mental Health (NIMH) (AI 68632). G.M.A. is an Elizabeth Glaser Pediatric AIDS Foundation Scientist.
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Nicole H. Tobin and Grace M. Aldrovandi declare that they have no conflict of interest
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Tobin, N.H., Aldrovandi, G.M. Are Infants Unique in Their Ability to be “Functionally Cured” of HIV-1?. Curr HIV/AIDS Rep 11, 1–10 (2014). https://doi.org/10.1007/s11904-013-0189-1
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DOI: https://doi.org/10.1007/s11904-013-0189-1