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Hepatic Resection for Extrahepatic Metastatic Disease: When Is It Reasonable?

  • Colorectal Cancer Hepatic Metastases (MA Choti, Section Editor)
  • Published:
Current Colorectal Cancer Reports

Abstract

The presence of limited and resectable extrahepatic metastases (EHM) in addition to colorectal liver metastases (LM) is no longer a contraindication to surgery. Long-term survival (between 25 and 30 % at 5 years) is possible for highly selected patients. The site of occurrence is a key prognostic factor. Results are best for lung EHM and limited peritoneal metastases (PM), lower when EHM invade the proximal hepatic lymph nodes, and worse for other EHM. Treatment decision making is difficult when faced with an infinite number of possible combinations between the different sites of metastases, their number, and the overall tumor load. General performance status, technical contingency, and chemosensitivity are also important factors to be reckoned with. In the future, a considerable amount of data concerning these patients and new statistical tools will be required to create clear decision trees.

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Acknowledgments

The authors thank Ms. Lorna Saint Ange for the editing.

Compliance with Ethics Guidelines

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Conflict of Interest

Dominique Elias declares that he has no conflict of interest.

Charles Honoré declares that he has no conflict of interest.

Diane Goéré declares that she has no conflict of interest.

Leonor Benhaim declares that she has no conflict of interest.

David Malka has received research support through grants from Amgen and Merck Serono; has received honoraria from Roche, Amgen, Celgene, Sanofi-Aventis, Teva, Boehringer-Ingelheim, Menarini, Merck Serono, Bayer, and Lilly; and has received nonfinancial support from Roche, Sanofi-Aventis, and Merck Serono.

Valérie Boige declares that she has no conflict of interest.

Michel Ducreux declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Surgical Oncology, Gustave Roussy, Cancer Campus, Grand Paris, Rue Edouard Vaillant, 94805, Villejuif, France

    Dominique Elias, Charles Honoré, Diane Goéré & Leonor Benhaim

  2. Department of Medical Oncology, Gustave Roussy, Cancer Campus, Grand Paris, Rue Edouard Vaillant, 94805, Villejuif, France

    David Malka, Valérie Boige & Michel Ducreux

Authors
  1. Dominique Elias
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  2. Charles Honoré
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  3. Diane Goéré
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  4. Leonor Benhaim
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  5. David Malka
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  6. Valérie Boige
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  7. Michel Ducreux
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Corresponding author

Correspondence to Dominique Elias.

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This article is part of the Topical Collection on Colorectal Cancer Hepatic Metastases

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Elias, D., Honoré, C., Goéré, D. et al. Hepatic Resection for Extrahepatic Metastatic Disease: When Is It Reasonable?. Curr Colorectal Cancer Rep 11, 78–83 (2015). https://doi.org/10.1007/s11888-015-0263-8

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  • DOI: https://doi.org/10.1007/s11888-015-0263-8

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