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New Research Is Shining Light on How Collateral Arteries Form in the Heart: a Future Therapeutic Direction?

  • Regenerative Medicine (SM Wu, Section Editor)
  • Published:
Current Cardiology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Collateral arteries create artery-artery anastomoses that could serve as natural bypasses that in the heart could relieve the various complications of ischemia heart disease. Recent work using animal models have begun to reveal details of how coronary collateral arteries form.

Recent Findings

Mouse genetics has been used to study the cellular and molecular mechanisms of collateral artery development. Collateral arteries are not pre-existing in the mouse heart, and only form in response to injury. Myocardial infarction creates tissue hypoxia that triggers the expression of growth factors and chemokines that guide collaterogenesis. Collateral development is more robust in neonatal hearts when compared with adults, and contributes to neonatal heart regeneration.

Summary

The identification of signaling pathways and cellular responses underlying coronary collateral artery development suggests potential translational strategies. Continued investigation into this subject could lead to the identification of targetable pathways that induce collateral arteries for cardiac revascularization.

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Authors and Affiliations

  1. Department of Biology, Stanford University, Stanford, CA, 94305, USA

    Kristy Red-Horse

  2. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Kristy Red-Horse

  3. National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, 560065, India

    Soumyashree Das

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Correspondence to Kristy Red-Horse.

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Red-Horse, K., Das, S. New Research Is Shining Light on How Collateral Arteries Form in the Heart: a Future Therapeutic Direction?. Curr Cardiol Rep 23, 30 (2021). https://doi.org/10.1007/s11886-021-01460-z

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