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Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk

  • Cardiovascular Genomics (P Natarajan, Section Editor)
  • Published:
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Abstract

Purpose of Review

Obesity is a significant international public health epidemic with major downstream consequences on morbidity and mortality. While lifestyle factors contribute, there is an evolving understanding of genomic and metabolomic pathways involved with obesity and its relationship with cardiometabolic risk. This review will provide an overview of some of these important findings from both a biologic and clinical perspective.

Recent Findings

Recent studies have identified polygenic risk scores and metabolomic biomarkers of obesity and related outcomes, which have also highlighted biological pathways, such as the branched-chain amino acid (BCAA) pathway that is dysregulated in this disease. These biomarkers may help in personalizing obesity interventions and for mitigation of future cardiometabolic risk.

Summary

A multifaceted approach is necessary to impact the growing epidemic of obesity and related diseases. This will likely include incorporating precision medicine approaches with genomic and metabolomic biomarkers to personalize interventions and improve risk prediction.

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Funding

J. Regan is supported by a grant from the National Heart, Lung and Blood Institute (1R38HL143612).

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  1. Department of Medicine, Duke University, Durham, NC, USA

    Jessica A. Regan & Svati H. Shah

  2. Duke Molecular Physiology Institute, Duke University, 300 N. Duke Street, DUMC, Box 104775, Durham, NC, 27701, USA

    Jessica A. Regan & Svati H. Shah

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Correspondence to Svati H. Shah.

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J. Regan declares no conflict of interest. S. Shah holds an unlicensed patent (10317414) on a related research finding, and receives research support through sponsored research agreements through Verily Life Sciences Inc. and Lilly Inc.

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Regan, J.A., Shah, S.H. Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk. Curr Cardiol Rep 22, 174 (2020). https://doi.org/10.1007/s11886-020-01422-x

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