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Shared Genetic Aetiology of Coronary Artery Disease and Atherosclerotic Stroke—2015

  • Genetics (AJ Marian, Section Editor)
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Abstract

In the last years, genome-wide association studies have allowed to identify multiple genetic variants associated with atherosclerosis. In this review, we highlight the identification of genomic variants associated with coronary artery disease and myocardial infarction as well as large-vessel stroke. We will focus on genetic variants that displayed overlap for these atherosclerotic diseases. Current research is focusing on the identification of the functional mechanisms underlying these associations. As frequent variants are often only associated with small increases in risk, the search for the identification of rare variants with large increases in risk is ongoing. Whole-exome sequencing recently revealed rare variants dramatically increasing cardiovascular risk. Taken together, the developments of the past few years light the vision of improved prevention and therapy of coronary artery disease and stroke.

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Conflict of Interest

Thorsten Kessler, Jeanette Erdmann, Martin Dichgans, and Heribert Schunkert do not have any conflicts of interest in connection with this work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Funding

This work has been supported by the German Federal Ministry of Education and Research (BMBF) in the context of the e:Med programme (e:AtheroSysMed, to Jeanette Erdmann, Martin Dichgans, and Heribert Schunkert), the FP7 European Union project CVgenes@target (261123, to Jeanette Erdmann, Martin Dichgans, and Heribert Schunkert), and the Foundation Leducq (CADgenomics: Understanding Coronary Artery Disease Genes, 12CVD02, to Jeanette Erdmann and Heribert Schunkert).

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Authors and Affiliations

  1. Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany

    Thorsten Kessler & Heribert Schunkert

  2. Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Maria-Goeppert-Str. 1, 23562, Lübeck, Germany

    Jeanette Erdmann

  3. Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., partner site Hamburg/Kiel/Lübeck, Lübeck, Germany

    Jeanette Erdmann

  4. Institut für Schlaganfall- und Demenzforschung, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 17, 81377, Munich, Germany

    Martin Dichgans

  5. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

    Martin Dichgans

  6. Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., partner site Munich Heart Alliance, Munich, Germany

    Heribert Schunkert

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  1. Thorsten Kessler
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  2. Jeanette Erdmann
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  3. Martin Dichgans
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  4. Heribert Schunkert
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Correspondence to Heribert Schunkert.

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Kessler, T., Erdmann, J., Dichgans, M. et al. Shared Genetic Aetiology of Coronary Artery Disease and Atherosclerotic Stroke—2015. Curr Atheroscler Rep 17, 14 (2015). https://doi.org/10.1007/s11883-015-0498-5

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