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Allergic Inflammation in Aspergillus fumigatus-Induced Fungal Asthma

  • Basic and Applied Science (M Frieri and PJ Bryce, Section Editors)
  • Published:
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Abstract

Although fungi are pervasive in many environments, few cause disease in humans. Of these, Aspergillus fumigatus is particularly well suited to be a pathogen of the human lung. Its physical and biological characteristics combine to provide an organism that can cause tremendous morbidity and high mortality if left unchecked. Luckily, that is rarely the case. However, repeated exposure to inhaled A. fumigatus spores often results in an immune response that carries significant immunopathology, exacerbating asthma and changing the structure of the lung with chronic impacts to pulmonary function. This review focuses on the current understanding of the mechanisms that are associated with fungal exposure, sensitization, and infection in asthmatics, as well as the function of various inflammatory cells associated with severe asthma with fungal sensitization.

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Acknowledgments

The authors gratefully acknowledge financial support from the National Institutes of health (NIH) (Grant 1R15HL117254-01) to JMS. We also thank Jessica Ebert for critical reading of the manuscript.

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Drs. Ghosh, Schuh, and Mr. Hoselton declare no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Department of Veterinary and Microbiological Sciences, North Dakota State University, Dept 7690, P.O. Box 6050, Fargo, ND, 58108-6050, USA

    Sumit Ghosh, Scott A. Hoselton & Jane M. Schuh

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  1. Sumit Ghosh
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  2. Scott A. Hoselton
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Correspondence to Jane M. Schuh.

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Ghosh, S., Hoselton, S.A. & Schuh, J.M. Allergic Inflammation in Aspergillus fumigatus-Induced Fungal Asthma. Curr Allergy Asthma Rep 15, 59 (2015). https://doi.org/10.1007/s11882-015-0561-x

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