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Subjective symptoms and their association with psychiatric symptoms 3 months after ICU discharge: sub-analysis of a single-center prospective observational study

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Abstract

Background

Despite a growing volume of literature on post-intensive care syndrome, we know little about how subjective symptoms affect intensive care unit survivors in the long term.

Aims

This study aimed to elucidate the prevalence of subjective symptoms and to determine the clinical importance of post-intensive care syndrome by evaluating the association between these symptoms and psychiatric symptoms. We evaluated new-onset or worsening subjective symptoms and psychiatric symptoms in 81 patients at 3 months after discharge from an intensive care unit.

Results

More than half of patients had at least one subjective symptom, such as weakness (n = 31), fatigue (n = 23), malaise (n = 14), body pain (n = 14), or insomnia (n = 9).

Conclusions

The presence of subjective symptoms is associated with worse psychiatric symptoms (post-traumatic stress disorder, anxiety, and depression) at 3 months after ICU discharge. We found insomnia was particularly strongly associated with psychiatric symptoms in our study group.

Trial registration

UMIN Clinical Trial Registry no. UMIN000023743, September 1, 2016.

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Availability of data and materials

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Abbreviations

HADS:

Hospital anxiety and depression scale

HRQoL:

Health-related quality of life

ICU:

Intensive care unit

IES-R:

Impact of event scale revised

PICS:

Post-intensive care syndrome

W-PICS:

Wakayama post-intensive care syndrome study

References

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Acknowledgments

The W-PICS investigators included Seiji Anai, Mari Asada, Ayana Fujimoto, Yuriko Imanaka, Masahiro Kaneko, Seiya Kato, Atsumi Kawabata, Maki Kida, Yutsuki Kishi, Kosei Kunitatsu, Mayumi Kusumoto, Haruka Matsumoto, Kyohei Miyamoto, Keita Nakamoto, Tsuyoshi Nakashima, Atsuhiro Ogawa, Natsuki Oka, Naoaki Shibata, Nozomu Shima, Yukihiro Shima, Aya Takemoto, Naoko Tamura, Rikako Tanaka, Nana Taniguchi, Yuki Tsutsui, Akiko Uchigaki, Akina Yazaki, and Takafumi Yonemitsu. We acknowledge proofreading and editing by Benjamin Phillis at the Clinical Study Support Center at Wakayama Medical University. Our study will be presented in part at the 48th annual meeting of the Japanese Society of Intensive Care Medicine, February 2021.

Author information

Authors and Affiliations

Authors

Contributions

KM, MS, NS, and TN designed the study and are entirely responsible for its content. KM drafted the manuscript. MS, NS, TN, AO, SA, MA, and SK contributed to drafting and revision of the manuscript. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Kyohei Miyamoto.

Ethics declarations

Ethics approval and consent to participate

The protocol for this research project has been approved by a suitably constituted institutional ethics committee (Wakayama Medical University, approval number 1864). It conforms to the provisions of the Declaration of Helsinki.

Consent for publication

Written informed consent was obtained from all participants or legally authorized guardians before study enrollment.

Competing interests

The authors declare that they have no conflict of interest.

Supplementary Information

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Supplementary file1 (PDF 157 KB)

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Cite this article

Miyamoto, K., Shibata, M., Shima, N. et al. Subjective symptoms and their association with psychiatric symptoms 3 months after ICU discharge: sub-analysis of a single-center prospective observational study. Ir J Med Sci 191, 355–357 (2022). https://doi.org/10.1007/s11845-021-02550-1

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  • DOI: https://doi.org/10.1007/s11845-021-02550-1

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