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Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease

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Abstract

Background

Cardiovascular disease is the leading cause of death in the Western world, and a major cause of this disease is atherosclerosis. Research has demonstrated that pregnancy-associated plasma protein A (PAPP-A) plays a role in cardiovascular disease, as evidenced by the association between PAPP-A and severity of heart damage.

Aim

The aim of this work was to investigate the correlation between PAPP-A concentrations in coronary and peripheral blood and certain clinicopathological factors and antioxidant enzyme activities in patients diagnosed with coronary artery disease.

Methods

For 65 patients, arterial blood was obtained by puncturing the femoral or radial artery, and coronary blood was obtained via percutaneous coronary intervention. PAPP-A, catalase (CAT), superoxide dismutase-1 (SOD-1), and superoxide dismutase-2 (SOD-2) levels were measured using spectrometric methods.

Results

Coronary PAPP-A levels were slightly higher than peripheral PAPP-A levels (81.25 ± 2.34 and 62 ± 3 ng/mL, respectively, P < 0.0001); these levels were correlated with each other (r = 0.6629, P < 0.001) but not with clinicopathological factors (P > 0.05). Coronary PAPP-A levels were significantly elevated among patients at risk for cardiovascular disease (P < 0.05). Antioxidant enzyme activities were significantly higher in coronary samples than in peripheral samples from subjects with ischemic cardiopathy secondary to atherosclerosis (P < 0.001). Neither coronary nor peripheral PAPP-A levels were correlated with antioxidant enzyme activities in patients with cardiopathy secondary to atherosclerosis (P > 0.05).

Conclusions

PAPP-A levels could be used as biomarkers to identify patients at risk of coronary artery disease.

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Acknowledgments

We acknowledge the financial support of the A022 program, SEDENA, México City, México.

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Authors and Affiliations

  1. Interventional Cardiology Laboratory, Hospital Central Militar, Secretaría de la Defensa Nacional, 11649, Mexico City, Mexico

    H. Gutiérrez-Leonard

  2. Multidisciplinary Research Laboratory, Escuela Militar de Graduados de Sanidad, Secretaría de la Defensa Nacional, 11200, Mexico City, Mexico

    E. Martínez-Lara & E. Floriano-Sánchez

  3. Section of Graduate Studies and Research, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340, Mexico City, Mexico

    A. E. Fierro-Macías, V. M. Mena-Burciaga & M. D. Ronquillo-Sánchez

  4. Laboratory of Neurosciences, Instituto Nacional de Pediatría, 04530, Mexico City, Mexico

    N. Cárdenas-Rodríguez

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  1. H. Gutiérrez-Leonard
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  2. E. Martínez-Lara
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  3. A. E. Fierro-Macías
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  4. V. M. Mena-Burciaga
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  5. M. D. Ronquillo-Sánchez
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  6. E. Floriano-Sánchez
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  7. N. Cárdenas-Rodríguez
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Corresponding authors

Correspondence to E. Floriano-Sánchez or N. Cárdenas-Rodríguez.

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Funding

This study was funded by “Military research and development in coordination with public universities, public institutions of higher education and/or other public research centers” of the Secretaria de la Defensa Nacional, (SEDENA), México City, México (A022 program).

Conflict of interest

No author received a grant or speaker honorarium from any company. No author is a member of any committee. Hugo Gutiérrez-Leonard declares that he has no conflict of interest. Emmanuel Martínez-Lara declares that he has no conflict of interest. Alfonso E. Fierro-Macías declares that he has no conflict of interest. Victoria M. Mena-Burciaga declares that she has no conflict of interest. María D. Ronquillo-Sánchez declares that she has no conflict of interest. Esaú Floriano-Sánchez declares that he has no conflict of interest. Noemí Cárdenas-Rodríguez declares that she has no conflict of interest.

Ethical approval

All procedures performed in this study were conducted in accordance with the ethical standards of the Bioethics and Research Committees of the Hospital Central Militar, SEDENA, Mexico City (Registration Number DINV-79725) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all participants in this study.

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Gutiérrez-Leonard, H., Martínez-Lara, E., Fierro-Macías, A.E. et al. Pregnancy-associated plasma protein-A (PAPP-A) as a possible biomarker in patients with coronary artery disease. Ir J Med Sci 186, 597–605 (2017). https://doi.org/10.1007/s11845-016-1515-6

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  • DOI: https://doi.org/10.1007/s11845-016-1515-6

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