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Evolving changes in the management of early oesophageal adenocarcinoma in a tertiary centre

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Abstract

Objectives

Series from high volume oesophageal centres highlight an increasing prevalence of early malignant (EM) lesions. The advent of endoscopic mucosal resection (EMR) and radiofrequency ablation (RFA) offer alternatives to traditional surgery. The evolution of this pattern of care in a high volume centre is analysed.

Methods

Data were collected from a prospectively maintained database. 96 patients were treated with an EM lesion from 2000 to 2011. Surgery was the standard approach during the initial period (2000–2006). In 2007, with the introduction of EMR ± RFA to our Centre, a rising trend toward definitive endoscopic treatment was seen. This study details the selection of cases into treatment groups and their outcomes.

Results

From 2000 to 2006, 23 patients were treated with EM lesions, 96 % by surgery. Seventy-three were treated from 2007 to 2011, 55 % surgically and 45 % by EMR ± RFA. In the entire experience, there was one death from surgery and morbidity was higher in the surgery group compared with EMR ± RFA (p < 0.001). Three surgical patients (4.8 %) relapsed with HGD or cancer, and one patient with T1N1 disease died of disease recurrence. At a median of 13 months, EMR ± RFA offered 100 % disease control, 72 % had no endoscopic or histological evidence of Barrett’s oesophagus and one patient represented with low grade dysplasia.

Conclusions

This study highlights the changing pattern of care in the management of early oesophageal cancer. EMR ± RFA appears an acceptable alternative to surgery in carefully selected cases. However, long-term outcome analysis using these methods is required and close interdisciplinary collaboration of specialists in gastroenterology, surgery, pathology and radiology is mandatory to achieve optimum outcomes.

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Acknowledgments

This work is funded by an Irish Cancer Society Research Scholarship.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, Trinity College Dublin, Trinity Centre for Health Sciences, St.James’s Hospital, Dublin 8, Ireland

    N. J. O’Farrell, J. V. Reynolds, N. Ravi, J. O. Larkin & V. Malik

  2. Department of Gastroenterology, Trinity College Dublin, St James’s Hospital, Dublin 8, Ireland

    D. O’Toole

  3. Department of Radiology, St James’s Hospital, Dublin 8, Ireland

    G. F. Wilson

  4. Department of Pathology, St James’s Hospital, Dublin 8, Ireland

    C. Muldoon

Authors
  1. N. J. O’Farrell
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  2. J. V. Reynolds
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Correspondence to J. V. Reynolds.

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O’Farrell, N.J., Reynolds, J.V., Ravi, N. et al. Evolving changes in the management of early oesophageal adenocarcinoma in a tertiary centre. Ir J Med Sci 182, 363–369 (2013). https://doi.org/10.1007/s11845-012-0890-x

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  • DOI: https://doi.org/10.1007/s11845-012-0890-x

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