Abstract
Background
A predominance of melanomas on the left side of the body has recently been described. No associations between tumour laterality and gender, age or anatomical site have been identified.
Aim
The aim of this study was to investigate the prevalence of left-sided melanomas in an Irish population and to examine potential associations with various patient and tumour characteristics.
Methods
A retrospective chart review of patients with cutaneous melanoma who were treated over a 10-year period was carried out. Lateral distribution of melanoma on either side of the body was compared using χ2 analysis and evaluated by gender, age group, anatomic location, histologic subtype and Breslow depth.
Results
More melanomas occurred on the left side (57%, P = 0.015), and this finding was particularly significant in females. For both genders combined, there were no statistically significant differences in laterality by age group, anatomic location, type of melanoma and Breslow depth. There were significantly more superficial spreading melanomas on the left side in both men and women.
Conclusions
This study demonstrates a predominance of left-sided melanomas in Irish patients. While a number of demographic and molecular associations have been proposed, further research is required to fully explain this phenomenon.
References
Thompson JF, Scolyer RA, Kefford RF (2005) Cutaneous melanoma. Lancet 365(9460):687–701. doi:10.1016/S0140-6736(05)17951-3
National Cancer Registry (2009) Cancer in Ireland 1994–2007. National Cancer Registry. http://www.ncri.ie/pubs/pubfiles/summary_report_19942007.pdf. Accessed 18 Oct 2010
Roychoudhuri R, Putcha V, Moller H (2006) Cancer and laterality: a study of the five major paired organs (UK). Cancer Causes Control 17(5):655–662. doi:10.1007/s10552-005-0615-9
Butler ST, Fosko SW (2010) Increased prevalence of left-sided skin cancers. J Am Acad Dermatol. doi:10.1016/j.jaad.2009.11.032
Brewster DH, Horner MJ, Rowan S et al (2007) Left-sided excess of invasive cutaneous melanoma in six countries. Eur J Cancer 43(18):2634–2637. doi:10.1016/j.ejca.2007.09.021
Altekruse S, Kosary C, Krapcho M et al (2010) SEER cancer statistics review, 1975–2007. SEER. http://seer.cancer.gov/csr/1975_2007/. Accessed 15 Oct 2010
Moehrle M, Soballa M, Korn M (2003) UV exposure in cars. Photodermatol Photoimmunol Photomed 19(4):175–181
Hallberg O, Johansson O (2010) Sleep on the right side-Get cancer on the left? Pathophysiology 17(3):157–160. doi:10.1016/j.pathophys.2009.07.001
Topczewska JM, Postovit LM, Margaryan NV et al (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med 12(8):925–932. doi:10.1038/nm1448
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de Blacam, C., Ho, W.L., Acton, C. et al. Prevalence of left-sided melanomas in an Irish population. Ir J Med Sci 180, 727–730 (2011). https://doi.org/10.1007/s11845-011-0713-5
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DOI: https://doi.org/10.1007/s11845-011-0713-5