Abstract
Introduction
Many studies have demonstrated the prevalence of vitamin D insufficiency in the older population.
Objective
This study sought to determine whether supplementation with intramuscular vitamin D improved 25OH vitamin D levels significantly.
Subjects
Ninety female inpatients aged over 65 years were assigned to receive 300,000 IU of intramuscular vitamin D3 (cholecalciferol) or no intervention.
Methods
Baseline 25OH vitamin D and intact parathyroid hormone (iPTH) levels were taken and repeated 3 months after supplementation.
Results
Patients who received treatment showed a significant improvement in 25OH vitamin D levels, from 25.5 to 81 nmol/L with 11% remaining deficient. No patient became hypercalcaemic after treatment.
Conclusions
Vitamin D deficiency is common throughout all age groups in the Irish population and particularly the older female population who have increased risk of osteoporosis and fractures. Intramuscular vitamin D significantly improves 25OH vitamin D levels compared to no treatment and may combat non-compliance with oral medication.
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Nugent, C., Roche, K., Wilson, S. et al. The effect of intramuscular vitamin D (cholecalciferol) on serum 25OH vitamin D levels in older female acute hospital admissions. Ir J Med Sci 179, 57–61 (2010). https://doi.org/10.1007/s11845-009-0410-9
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DOI: https://doi.org/10.1007/s11845-009-0410-9