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The visceral adiposity index predicts the severity of hyperlipidaemic acute pancreatitis

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Abstract

It is important to clarify the severity of acute pancreatitis (AP) in the early stages of the disease. The visceral adiposity index (VAI), calculated using the waist circumference (WC), body mass index (BMI), triglyceride (TG) levels, and high-density lipoprotein cholesterol (HDL-c), indirectly reflects visceral adiposity function and can be used to explore its value in evaluating and predicting the severity of hyperlipidaemic acute pancreatitis (HLAP). The VAIs of 227 patients with HLAP were calculated by retrospective analysis of body parameters and laboratory indicators. The correlation between the VAI and HLAP severity, local complications, and systemic inflammatory response syndrome (SIRS) response was analysed. The VAI was significantly higher in patients with severe and moderately severe AP than in patients with mild AP (both p < 0.05). Length of hospital stay (LOS), AP severity, systemic complications, Acute Physiology and Chronic Health Evaluation II (APACHE-II) score, and SIRS score were significantly correlated with the VAI in HLAP patients. The VAI had the highest area under the curve of receiver operating characteristics (ROC) (0.755, 95% confidence interval [CI], 0.691–0.819) for predicting AP severity. The multivariate-adjusted odds ratio (HR) for the VAI in the relationship of body parameters and the severity of HLAP was 3.818 (95% CI, 1.395–10.452). Our study shows that the VAI is a valuable indicator for predicting and assessing the severity of hyperlipidaemic acute pancreatitis. Its increase is closely related to poor prognosis in patients with HLAP.

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Acknowledgements

We thank all the individuals that contributed to this study. We thank all the doctors and nurses in the Department of Pancreatitis Center of the First Affiliated Hospital of Wenzhou Medical University for their hard work.

Funding

Dr. Yu is supported by a grant from The Scientific Research Foundation of Wenzhou, Zhejiang Province, China (project No. Y2020041).

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Authors and Affiliations

  1. Department of Radiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 32000, China

    Weizhi Xia

  2. Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 32000, China

    Huajun Yu

  3. Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 32000, China

    Yingbao Huang & Yunjun Yang

  4. Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 32000, China

    Liuzhi Shi

Authors
  1. Weizhi Xia
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  5. Liuzhi Shi
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Contributions

LS and HY conceived, designed, and directed the study. HY and YH performed the data analysis. WX performed the statistical analysis. All other co-authors recruited study subjects and collected clinical data. WX drafted the manuscript with substantial help from LS. All authors contributed to the intellectual content with critical revisions and approved the final version of the manuscript.

Corresponding author

Correspondence to Liuzhi Shi.

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None.

Ethical approval

Ethical approval was obtained at in the First Affiliated Hospital of Wenzhou Medical University (date 14.02.2019, Ethics number KY2019-011, Ethics Committee, the First Affiliated Hospital of Wenzhou Medical University).

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Due to the retrospective nature of the study and anonymisation of all data, no informed consent was requested.

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Xia, W., Yu, H., Huang, Y. et al. The visceral adiposity index predicts the severity of hyperlipidaemic acute pancreatitis. Intern Emerg Med 17, 417–422 (2022). https://doi.org/10.1007/s11739-021-02819-4

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  • DOI: https://doi.org/10.1007/s11739-021-02819-4

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