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Direct oral anticoagulants versus warfarin for the treatment of left ventricular thrombosis

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Availability of data and material

Study data were collected from Epic, an electronic medical record system utilized by Wake Forest Baptist Medical Center, and managed using REDCap electronic data capture tools hosted at Wake Forest School of Medicine.

Code availability

Study data were collected from Epic, an electronic medical record system utilized by Wake Forest Baptist Medical Center, and managed using REDCap electronic data capture tools hosted at Wake Forest School of Medicine.

References

  1. Asinger RW, Mikell FL, Elsperger J, Hodges M (1981) Incidence of left-ventricular thrombosis after acute transmural myocardial infarction. Serial evaluation by two-dimensional echocardiography. N Engl J Med 305:297–302

    Article  CAS  Google Scholar 

  2. Delewi R, Zijlstra F, Piek JJ (2012) Left ventricular thrombus formation after acute myocardial infarction. Heart 98:1743–1749

    Article  Google Scholar 

  3. American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease (2014) Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American heart association/American stroke association. Stroke 45(7):2160–2236

    Article  Google Scholar 

  4. The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC) (2018) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 39(2):119–177

    Article  Google Scholar 

  5. Steuber TD, Howard ML, Nisly SA (2019) Direct oral anticoagulants in chronic liver disease. Ann Pharm 53(10):1042–1049

    CAS  Google Scholar 

  6. van Es N, Buller HR (2015) Using direct oral anticoagulants (DOACS) in cancer and other high-risk populations. Hematol Am Soc Hematol Educ Program 2015:125–131

    Article  Google Scholar 

  7. Kido K, Lee JC, Hellwig T, Gulseth MP (2020) Use of direct oral anticoagulants in morbidly obese patients. Pharmacotherapy 40(1):72–83

    Article  Google Scholar 

  8. Weber J, Olyaei A, Shatzel J (2019) The efficacy and safety of direct oral anticoagulants in patients with chronic renal insufficiency: a review of the literature. Eur J Haematol 102(4):312–318

    Article  CAS  Google Scholar 

  9. Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (2005) Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 3(4):692–694

    Article  Google Scholar 

  10. Fleddermann AM, Hayes CH, Magalski A, Main ML (2019) Efficacy of direct acting oral anticoagulants in treatment of left ventricular thrombus. Am J Cardiol 124(3):367–372

    Article  CAS  Google Scholar 

  11. Iqbal H, Straw S, Craven TP, Stirling K, Wheatcroft SB, Witte KK (2020) Direct oral anticoagulants compared to vitamin K antagonist for the management of left ventricular thrombus. ESC Heart Fail 7(5):2032–2041

    Article  Google Scholar 

  12. Robinson AA, Trankle CR, Eubanks G, Schumann C, Thompson P, Wallace RL, Gottiparthi S, Ruth B, Kramer CM, Salerno M, Bilchick KC, Deen C, Kontos MC, Dent J (2020) Off-label use of direct oral anticoagulants compared with warfarin for left ventricular thrombi. JAMA Cardiol 5(6):685–692

    Article  Google Scholar 

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Authors and Affiliations

Authors

Contributions

Study conception and design and material preparation were performed by AEM, SAN, and KAD. Data collection were performed by HEH and ALC. Data analysis was performed by SAN. All authors contributed to manuscript development and approved the final manuscript.

Corresponding author

Correspondence to Alexandra Evaun Mihm.

Ethics declarations

Conflict of interest

Kyle A Davis is currently employed by United Therapeutics Corporation. However, at the time of project development, research analysis, and manuscript writing, he was an employee of Wake Forest Baptist Medical Center, where the research was conducted.

Ethics approval

This research qualified for expedited review under the Federal Regulations [45CFR46.110]. This research met the criteria for a waiver of consent entirely according to 45 CFR 46(d) and met the criteria for a waiver of HIPAA authorization according to 45 CFR 164.512.

Human and animal rights

This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Human Investigation Committee (IRB) of Wake Forest University approved this study.

Informed consent

This research met the criteria for a waiver of consent entirely according to 45 CFR 46(d). Consequently, for this type of study, no informed consent was required.

Consent to participate and for publication

This research met the criteria for a waiver of consent entirely according to 45 CFR 46(d) and met the criteria for a waiver of HIPAA authorization according to 45 CFR 164.512. Consequently, consent to participate and consent for publication were not obtained.

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Mihm, A.E., Hicklin, H.E., Cunha, A.L. et al. Direct oral anticoagulants versus warfarin for the treatment of left ventricular thrombosis. Intern Emerg Med 16, 2313–2317 (2021). https://doi.org/10.1007/s11739-021-02788-8

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  • DOI: https://doi.org/10.1007/s11739-021-02788-8

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