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Multifunctional modification of Fe3O4 nanoparticles for diagnosis and treatment of diseases: A review

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Abstract

With the rapid improvements in nanomaterials and imaging technology, great progresses have been made in diagnosis and treatment of diseases during the past decades. Fe3O4 magnetic nanoparticles (MNPs) with good biocompatibility and superparamagnetic property are usually used as contrast agent for diagnosis of diseases in magnetic resonance imaging (MRI). Currently, the combination of multiple imaging technologies has been considered as new tendency in diagnosis and treatment of diseases, which could enhance the accuracy and reliability of disease diagnosis and provide new strategies for disease treatment. Therefore, novel contrast agents used for multifunctional imaging are urgently needed. Fe3O4 MNPs are believed to be a potential candidate for construction of multifunctional platform in diagnosis and treatment of diseases. In recent years, there are a plethora of studies concerning the construction of multifunctional platform presented based on Fe3O4 MNPs. In this review, we introduce fabrication methods and modification strategies of Fe3O4 MNPs, expecting great improvements for diagnosis and treatment of diseases in the future.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant Nos. 11502158, 11632013 and 11802197). The support of the Shanxi Provincial Key Research and Development Project, China (Grant Nos. 201803D421060, 201903D421064 and 201803D421076), the Natural Science Foundation of Shanxi Province, China (201901D111078 and 201901D111077), and the Shanxi Scholarship Council of China (No. HGKY2019037) are also acknowledged with gratitude.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China

    Miao Qin, Mengjie Xu, Yizhu Cheng, Xiaolian Niu, Jinlong Kong, Xiumei Zhang, Yan Wei & Di Huang

  2. Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China

    Yan Wei & Di Huang

  3. Wellead Medical Co. Ltd., Guangzhou, 511434, China

    Lulu Niu

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  1. Miao Qin
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  2. Mengjie Xu
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  3. Lulu Niu
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  4. Yizhu Cheng
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  5. Xiaolian Niu
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  6. Jinlong Kong
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  8. Yan Wei
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  9. Di Huang
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Correspondence to Di Huang.

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Qin, M., Xu, M., Niu, L. et al. Multifunctional modification of Fe3O4 nanoparticles for diagnosis and treatment of diseases: A review. Front. Mater. Sci. 15, 36–53 (2021). https://doi.org/10.1007/s11706-021-0543-y

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  • DOI: https://doi.org/10.1007/s11706-021-0543-y

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