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A Novel Intragastric Satiety-Inducing Device to Inhibit Weight Gain in Juvenile Pigs: a Pilot Study

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Abstract

Background and Aims

Minimally invasive therapies for obesity are a bridge between lifestyle interventions and bariatric surgery. We developed a novel device to reduce weight gain rate and evaluated its safety and efficacy in juvenile pigs.

Methods

The intragastric satiety-inducing device (ISD) comprises a self-expandable esophageal metal stent connected to a star-shaped disc placed in the stomach fundus. Eight juvenile pigs were randomized into ISD (n = 5) and control (n = 3) groups. Body weight and serum ghrelin hormone were monitored weekly for 6 weeks. One pig was followed up for 4 additional weeks (rebound pig) after ISD removal. Histological examination and immunohistochemistry for the interstitial cells of Cajal (ICCs) were performed.

Results

ISD placement was successful in all pigs. Two ISDs (40%) migrated at 4 and 5 weeks after placement. Weight gain rates were significantly lower in the ISD group than in the control group from week 1 to 6 but were higher in the rebound pig than in a control pig from week 7 to 10. Mean ghrelin hormone level was higher in the control group than in the ISD group from week 1 to 6. ISD induced reversible inflammatory changes in the esophagus and stomach fundus. The number of ICCs was lesser in ISD pigs than in control and rebound pigs.

Conclusions

ISD placement is feasible and safe in juvenile pigs. It decreases weight gain rate but induces reversible inflammatory reaction and tissue hyperplasia. Its mechanism may be related to pressure exertion on the stomach fundus or gastric motility alteration.

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Funding

This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant no. HI18C0631 to H.Y.J.) as well as by a grant (2016-7017) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.

Author information

Author notes

  1. Nader Bakheet, Hee Kyong Na, and Jung-Hoon Park contributed equally to this work and are the co-first authors.

  2. Hoon Kim and Hwoon-Yong Jung contributed equally to this work and are the co-corresponding authors.

Authors and Affiliations

  1. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea

    Nader Bakheet, Hee Kyong Na, Do Hoon Kim & Hwoon-Yong Jung

  2. Gastrointestinal Endoscopy and Liver Unit, Kasr Al-Ainy, Faculty of Medicine, Cairo University, Cairo, Egypt

    Nader Bakheet

  3. Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea

    Jung-Hoon Park & Ho-Young Song

  4. Department of Biomedical Engineering Research Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea

    Jung-Hoon Park & Dae sung Ryu

  5. Department of Rehabilitation, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea

    Jae Yong Jeon

  6. Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Mouen A. Khashab & Vivek Kumbhari

  7. Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Jiaywei Tsauo

  8. Department of Radiology, UT Health Science Center at San Antonio, San Antonio, TX, USA

    Ho-Young Song

  9. Department of Minimal-Invasive Intervention, The Affiliated Cancer Hospital of Zhengzhou University, 127 Dongming Road, Zhengzhou, 450003, Henan Province, China

    Hong Tao Hu

Authors
  1. Nader Bakheet
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  2. Hee Kyong Na
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  3. Jung-Hoon Park
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  4. Dae sung Ryu
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  5. Jae Yong Jeon
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  6. Mouen A. Khashab
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  7. Vivek Kumbhari
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  8. Jiaywei Tsauo
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  9. Ho-Young Song
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  10. Hong Tao Hu
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  11. Do Hoon Kim
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  12. Hwoon-Yong Jung
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Corresponding authors

Correspondence to Do Hoon Kim or Hwoon-Yong Jung.

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Conflict of Interest

Mouen A. Khashab is a consultant for Boston Scientific, Olympus America, and Medtronic and is on the advisory board for Boston Scientific and Olympus. He has received research support from Cook Medical. Vivek Kumbhari is a consultant for Apollo Endosurgery, Boston Scientific, Medtronic, Pentax and ReShape Life Sciences. He has received research support from Erbe and Apollo Endosurgery. All other authors declare that they have no conflict of interest.

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All applicable institutional and/or national guidelines for the care and use of animals were followed.

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Bakheet, N., Na, H.K., Park, JH. et al. A Novel Intragastric Satiety-Inducing Device to Inhibit Weight Gain in Juvenile Pigs: a Pilot Study. OBES SURG 30, 4643–4651 (2020). https://doi.org/10.1007/s11695-020-04930-5

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  • DOI: https://doi.org/10.1007/s11695-020-04930-5

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