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The Positive Effects of a Calorie-Restricting High-Protein Diet Combined with Intragastric Botulinum Toxin Type A Application Among Morbidly Obese Patients: A Prospective, Observational Analysis of Eighty-Seven Grade 2 Obese Patients

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A Correction to this article was published on 21 January 2021

This article has been updated

Abstract

Purpose

Many studies evaluating the effect of intragastric botulinum toxin type A injection (IG-BTxA) for the treatment of obesity have been published. However, none of these studies combined this procedure with a calorie-restricting high-protein diet. Herein, we aimed to evaluate the effects of IG-BTxA application combined with a calorie-restricting high-protein diet.

Materials and Methods

This prospective cohort study is conducted with eighty-seven grade 2 obese patients treated between January 2019 and August 2019. Group 1: IG-BTxA + refused to consult the dietitian; group 2: IG-BTxA + get calorie-restricting high-protein diet; group 3: only get a calorie-restricting high-protein diet. Loss of weight, treatment adaptation (visual analog scale score), the status and changes of comorbid conditions, and changes in eating behaviors (Self-Regulation of Eating Behaviour Questionnaire score) were assessed.

Results

Loss of weight, treatment adaptation, and positive behavioral change in eating preferences were significantly higher in group 2 (p = 0.01; p = 0.001; p < 0.01, respectively). Additionally, the decrease in medication requirement for diabetes and hypertension was higher in group 2 (p < 0.05).

Conclusion

IG-BTxA application before calorie-restricting high-protein diet facilitates adaptation to the new diet style and helps to lose weight faster in grade 2 obese patients. Also, more positive results were achieved in terms of controlling comorbid diseases.

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Change history

  • 21 January 2021

    A Correction to this paper has been published: <ExternalRef><RefSource>https://doi.org/10.1007/s11695-020-04597-y</RefSource><RefTarget Address="10.1007/s11695-020-04597-y" TargetType="DOI"/></ExternalRef>

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Authors and Affiliations

  1. Department of General Surgery, Faculty of Medicine, Istanbul Okan University, Istanbul, Turkey

    Murat Ferhat Ferhatoglu, Abdulcabbar Kartal, Ali Ilker Filiz & Abut Kebudi

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  1. Murat Ferhat Ferhatoglu
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  2. Abdulcabbar Kartal
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  3. Ali Ilker Filiz
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  4. Abut Kebudi
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Contributions

MFF collected the information, reviewed the literature, and wrote the manuscript. AcK collected the information. AIF and AK critically reviewed the manuscript and approved the final form. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Abdulcabbar Kartal.

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The authors declare that they have no conflict of interest.

Ethical Approval Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Ferhatoglu, M.F., Kartal, A., Filiz, A.I. et al. The Positive Effects of a Calorie-Restricting High-Protein Diet Combined with Intragastric Botulinum Toxin Type A Application Among Morbidly Obese Patients: A Prospective, Observational Analysis of Eighty-Seven Grade 2 Obese Patients. OBES SURG 30, 3472–3479 (2020). https://doi.org/10.1007/s11695-020-04597-y

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