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Participant factors that contribute to magnetic resonance imaging motion artifacts in children with mild traumatic brain injury or orthopedic injury

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Abstract

Motion can compromise image quality and confound results, especially in pediatric research. This study evaluated qualitative and quantitative approaches to motion artifacts detection and correction, and whether motion artifacts relate to injury history, age, or sex in children with mild traumatic brain injury or orthopedic injury relative to typically developing children. The concordance between qualitative and quantitative motion ratings was also examined. Children aged 8–16 years with mild traumatic brain injury (n = 141) or orthopedic injury (n = 73) were recruited from the emergency department and completed an MRI scan roughly 2 weeks post-injury. Typically developing children (n = 41) completed a single MRI scan. T1- and diffusion-weighted images were visually inspected and rated for motion artifacts by trained examiners. Quantitative estimates of motion artifacts were derived from FreeSurfer and FSL. Age (younger > older) and sex (boys > girls) were significantly associated with motion artifacts on both T1- and diffusion-weighted images. Children with mild traumatic brain or orthopedic injury had significantly more motion-corrupted diffusion-weighted volumes than typically developing children, but mild traumatic brain injury and orthopedic injury groups did not differ from each other. The exclusion of motion-corrupted volumes did not significantly change diffusion tensor imaging metrics. Results indicate that automated quantitative estimates of motion artifacts, which are less labour-intensive than manual methods, are appropriate. Results have implications for the reliability of structural MRI research and highlight the importance of considering motion artifacts in studies of pediatric mild traumatic brain injury.

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Data available upon reasonable request.

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Analysis code is available upon reasonable request.

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Funding

This work is supported by a Canadian Institute of Health Research (CIHR) Foundation Grant (FDN143304), as well as by the Ronald and Irene Ward Chair in Pediatric Brain Injury from the Alberta Children’s Hospital Foundation, the Canada Research Chair program, the Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute, and the Killam Postdoctoral Fellowship at the University of Calgary.

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  1. Ashley L. Ware and Ayushi Shukla contributed equally to this work.

Authors and Affiliations

  1. Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB, T2N 1N4, Canada

    Ashley L. Ware, Adrian Onicas & Keith Owen Yeates

  2. Hotchkiss Brain Institute, University of Calgary, Calgary, Canada

    Ashley L. Ware, Ayushi Shukla, Sunny Guo, Bryce L. Geeraert, Bradley G. Goodyear, Keith Owen Yeates & Catherine Lebel

  3. Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Canada

    Ashley L. Ware, Ayushi Shukla, Sunny Guo, Bryce L. Geeraert, Bradley G. Goodyear, Keith Owen Yeates & Catherine Lebel

  4. Department of Clinical Neurosciences, University of Calgary, Calgary, Canada

    Sunny Guo

  5. Department of Neurology, University of Utah, Salt Lake City, UT, USA

    Ashley L. Ware

  6. IMT School for Advanced Studies Lucca, Lucca, Italy

    Adrian Onicas

  7. Department of Radiology, University of Calgary, Calgary, Canada

    Ayushi Shukla, Bryce L. Geeraert, Bradley G. Goodyear & Catherine Lebel

  8. Seaman Family MR Research Centre, Foothills Medical Centre, Alberta Health Services, Calgary, Canada

    Bradley G. Goodyear

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I verify that appropriate Institutional Review Board (IRB) approval has been obtained for the use of human or animal subjects. Study was conducted in accordance with the IRB at the University of Calgary: REB15–2296 for the A-CAP study and REB13–1346 for the adolescent study.

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Ware, A.L., Shukla, A., Guo, S. et al. Participant factors that contribute to magnetic resonance imaging motion artifacts in children with mild traumatic brain injury or orthopedic injury. Brain Imaging and Behavior 16, 991–1002 (2022). https://doi.org/10.1007/s11682-021-00582-w

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