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The relationship between putamen-SMA functional connectivity and sensorimotor abnormality in ESRD patients

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Abstract

The basal ganglia (BG) are composed of several nuclei involved in neural processing associated with integration of sensory and motor information. Recent neuroimaging studies implicated its key role in control of voluntary motor function. As the sensorimotor abnormality is common among the end-stage renal disease (ESRD) population, in the current study, we aimed to investigate the abnormal structure and functional connectivity patterns of BG in ESRD patients. Twenty-nine ESRD and twenty-nine age and gender-matched healthy controls (HC) were enrolled to compare the volume of the subsets in the BG (e.g., caudate nucleus, putamen and globus pallidus) by using the VBM analysis; resting-state functional connectivity was analyzed by a seed-based method. Compared with the HC group, ESRD patients had a smaller volume in the right putamen. Taking the right putamen as a seed region, we further found reduced functional connectivity in patients mainly between the putamen and supplementary motor area (SMA), insula, posterior mid-cingulate gyrus, and primary motor cortex. In ESRD group, the severity score of restless legs syndrome was negatively correlated with putamen-SMA functional connectivity, while the hemoglobin level was positively correlated with functional connectivity degree between the putamen and SMA. Our results revealed an abnormal volume of the putamen and its decreased functional connectivity patterns during resting state in ESRD with sensorimotor abnormalities. These preliminary results indicated that the decreased functional connectivity in putamen-SMA was associated with sensorimotor abnormalities, and anemia was correlated with this abnormal functional pattern in ESRD patients.

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Acknowledgements

This study was funded by the National Natural Science Foundation of China (Grant No. 81371530) and the Research Funds of the First Affiliated Hospital of Xi’an Jiaotong University, College of Medicine (Grant No. 2014YK3).

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  1. Dun Ding, Peng Li and Xue-ying Ma contributed equally to this work and should be considered as first co-authors.

Authors and Affiliations

  1. Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

    Dun Ding, Xue-ying Ma, Wang-huan Dun, Shao-hui Ma, Hong-juan Liu & Ming Zhang

  2. Department of Medical Imaging, Shaanxi Nuclear Geology 215 Hospital, Xianyang, China

    Peng Li

  3. Department of Nephrology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

    Shi-feng Yang

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  1. Dun Ding
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Correspondence to Ming Zhang.

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Dun Ding, Peng Li, Xueying Ma, Wanghuan Dun, Shifeng Yang, Shao-hui Ma, and Ming Zhang declares that they have no conflict of interest.

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Ding, D., Li, P., Ma, Xy. et al. The relationship between putamen-SMA functional connectivity and sensorimotor abnormality in ESRD patients. Brain Imaging and Behavior 12, 1346–1354 (2018). https://doi.org/10.1007/s11682-017-9808-6

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