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Functional-structural degeneration in dorsal and ventral attention systems for Alzheimer’s disease, amnestic mild cognitive impairment

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Abstract

Growing evidence of attention related failures in patients with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) has already been proposed by previous studies. However, previous studies lacked of systematic investigation on the functional and structural substrates for attention function for patients with AD and aMCI. In this work, we investigated the functional connectivity and gray matter density in dorsal and ventral attention networks (DAN, VAN) of normal participants (n = 15) and patients with aMCI (n = 12) and AD (n = 16) by applying group independent component analysis (ICA) and voxel-based morphometry (VBM) analysis. Using ICA, we extracted the functional patterns of DAN and VAN which are respectively responsible for the “top-down” attention process and “bottom-up” process. One-way analysis of variance (ANOVA) revealed significant group-differed functional connectivity in bilateral frontal eye fields (FEF) area and intraparietal sulcus (IPS) area, as well as posterior cingulate cortex and precuneus in the dorsal system. With regard to the ventral system, group-effects were significantly focused in right orbital superior/middle frontal gyrus, right inferior parietal lobule, angular gyrus, and supramarginal gyrus around the temporal-parietal junction area. Post hoc cluster-level comparisons revealed totally impaired functional substrates for both attentional networks for patients with AD, whereas selectively impaired attention systems for patients with aMCI with impaired functional patent of DAN but preserved functional pattern of VAN. Correspondingly, VBM analysis revealed gray matter loss in right ventral and dorsal frontal cortex was in the AD group, whereas preserved gray matter density was in aMCI, even a little extent of expansion of gray matter density in several participants. Using multivariate regression analysis we found discrepant couplings of functional-structural degenerations between both patient groups. Specifically, positive coupling of structural-functional degeneration was found in right dorsal and ventral frontal cortex in the AD group, whereas inverse coupling in dorsal frontal cortex was found in the aMCI group. These findings suggested discrepant functional-structural degenerations in both attention systems between both patient groups, widening avenues to better understanding the attentional deficits in patients with aMCI and AD.

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Ethical Statements

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

Conflict of interest

Shaowen Qian, Zhaoyan Zhang, Bo Li, and Gang Sun declare that they have no conflicts of interest.

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Correspondence to Gang Sun.

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Figure S1

Both attention systems in the within-group analysis for z-transformed functional connectivity. (a1-c1) Top to bottom: the DAN maps in NC, aMCI and AD group respectively. (a2-c2) Top to bottom: the VAN maps in NC, aMCI, and AD group respectively. (DOC 500 kb)

Table S1

Brain regions in DAN maps in NC, aMCI, and AD groups (DOC 50 kb)

Table S2

Brain regions in VAN maps in NC, aMCI, and AD groups (DOC 44 kb)

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Qian, S., Zhang, Z., Li, B. et al. Functional-structural degeneration in dorsal and ventral attention systems for Alzheimer’s disease, amnestic mild cognitive impairment. Brain Imaging and Behavior 9, 790–800 (2015). https://doi.org/10.1007/s11682-014-9336-6

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