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Clinicopathological significance of mucin 2 immunohistochemical expression in colorectal cancer: A meta-analysis

  • Original Article
  • Published:
Chinese Journal of Cancer Research

Abstract

Objective

To evaluate the association between mucin 2 (MUC2) expression and clinicopathological characters of colorectal cancer.

Methods

A literature search was performed on December 31, 2010 according to defined selection criteria. We evaluated the correlation between MUC2 (detected by immunohistochemistry) and clinicopathological characters of colorectal cancer. According to the tumor histological type, differentiation, location and TNM staging of colorectal carcinoma, we divided the clinicopathological characteristics into different subgroups. Fixed and random effects models were applied for estimation of the summarized risk ratios (RRs) and 95% confidence intervals (CIs) in different subgroups. Finally, forest plots and funnel plots were created to allow for visual comparison of the results or the effect of publication bias.

Results

According with the inclusive criteria, fourteen studies (n=1,558) were eligible for the meta-analysis. We observed a trend towards a correlation of MUC2 higher positivity in mucinous than non-mucinous carcinoma (RR, 2.10; 95% CI, 1.30–3.40; P=0.002) and less positivity in distal than proximal colon (RR, 0.74; 95% CI, 0.64–0.85; P=0.000). There was no statistically significance for the association between MUC2 expression and differentiation or TNM staging of colorectal cancer, but MUC2 overexpression tended to be associated with the presence of T stage tumor (RR, 1.17; P=0.052).

Conclusion

MUC2 overexpression was associated with the mucinous and proximal colorectal cancer.

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Authors and Affiliations

  1. Department of Pathology, Affiliated First Hospital, Nanjing Medical University, Nanjing, 210006, China

    Li Li

  2. Department of Pathology, School of Medicine, Southeast University, Nanjing, 210009, China

    Pei-lin Huang & Xiao-dong Bu

  3. Department of Epidemiology and Statistics, School of Public Health, Southeast University, Nanjing, 210009, China

    Xiao-jin Yu

Authors
  1. Li Li
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  2. Pei-lin Huang
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  3. Xiao-jin Yu
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  4. Xiao-dong Bu
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Correspondence to Li Li.

Additional information

This research was supported by Medical Science and Technology Development Foundation of Nanjing, China (No.YKK10096).

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Li, L., Huang, Pl., Yu, Xj. et al. Clinicopathological significance of mucin 2 immunohistochemical expression in colorectal cancer: A meta-analysis. Chin. J. Cancer Res. 24, 190–195 (2012). https://doi.org/10.1007/s11670-012-0190-z

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  • DOI: https://doi.org/10.1007/s11670-012-0190-z

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