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Trabecular bone score in the hip: a new method to examine hip bone microarchitecture—a feasibility study

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Abstract

Summary

Our study found, in older adults who are residents of long-term care facilities, assessing hip microarchitecture with DXA-derived bone texture score may serve as a supplement to bone mineral density to improve fracture prediction and to facilitate decision-making for pharmacological management.

Purpose

Many patients with high fragility fracture risk do not have a sufficiently low bone mineral density (BMD) to become eligible for osteoporosis treatment. They often have deteriorated bone microarchitecture despite a normal or only mildly abnormal BMD. We sought to examine the beta version of the trabecular bone score (TBS) algorithm for the hip: TBS Hip, an indirect index of bone microarchitecture, and assess if TBS Hip brings complementary information to other bone quality indices such as BMD and bone turnover markers (BTMs) to further improve identifying individuals who are at high risk for fractures.

Methods

In this analysis, we considered baseline TBS Hip at total hip, femoral neck, and greater trochanter, TBS at lumbar spine, BMD at all of these skeletal sites, and BTMs in 132 postmenopausal women who were residents of long-term care (LTC) facilities enrolled in a randomized placebo-controlled osteoporosis clinical trial.

Results

On average, participants were 85.2 years old and had a BMI of 26.9 kg/m2. The correlation coefficient between BMD and TBS Hip at total hip, femoral neck, and greater trochanter was 0.50, 0.32, and 0.39 respectively (all p < 0.0001). The correlation coefficient between BMD and lumbar spine TBS was 0.52 (p < 0.0001). There was no statistically significant correlation between BTMs with TBS at lumbar spine or TBS Hip at total hip, femoral neck, and greater trochanter.

Conclusion

Among older women residing in LTC facilities, there was a moderate correlation between measures of BMD and TBS Hip at total hip, femoral neck, and greater trochanter, suggesting TBS Hip may provide complementary information to BMD .

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Funding

This work was supported by the following grants: National Institutes of Health (Grant R01AG050302, Grant T32AG021885, Grant K07AG052668), and Pepper Older Americans Independence Centers (Grant P30AG024827).

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Authors and Affiliations

  1. Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, 3471 Fifth Ave, Suite 1110, Pittsburgh, PA, 15213, USA

    Nami Safai Haeri, Subashan Perera & Susan L. Greenspan

  2. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Nami Safai Haeri & Susan L. Greenspan

  3. Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA

    Subashan Perera

  4. Medimaps Group, Bordeaux, France

    Isabel Ferreiro

  5. Bone & Joint Department, Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland

    Didier Hans

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  1. Nami Safai Haeri
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Correspondence to Nami Safai Haeri.

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Conflicts of interest

Nami Safai Haeri, Subashan Perera, and Susan Greenspan report no conflicts of interest in the subject matter or materials discussed in this manuscript. Didier Hans is co-owner of the TBS patents and has corresponding ownership shares and position at Medimaps Group. Isabel Ferreiro is a senior clinical specialist at Med-Imaps SASU, part of the Medimaps Group.

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Haeri, N.S., Perera, S., Ferreiro, I. et al. Trabecular bone score in the hip: a new method to examine hip bone microarchitecture—a feasibility study. Arch Osteoporos 17, 126 (2022). https://doi.org/10.1007/s11657-022-01168-9

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  • DOI: https://doi.org/10.1007/s11657-022-01168-9

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