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The impact of height on low/reduced bone mineral density in Chinese adolescents aged 12-14 years old: gender differences

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Abstract

Summary

Low/reduced bone mineral density (BMD) is an important predictor of childhood fracture. In this article, we presented the prevalence of BMD in Chinese adolescents and, for the first time, demonstrated the gender disparities in the impact of height on BMD.

Purpose

To analyze the gender disparities in the association of low/reduced BMD with height in Chinese adolescents at the stage of growth spurt.

Methods

A total of 8152 adolescents aged 12–14 years old were included based on a cross-sectional study in Tianjin, China. Height and weight were measured with standard equipment. BMD was measured using the method of quantitative ultrasound. Adolescents with Z ≤ − 2.0 or − 2.0 < Z ≤ − 1.0 were defined as “low BMD” or “reduced BMD”.

Results

The total low/reduced BMD rate was 22.0% in Chinese adolescents aged 12–14 years old, and boys were more likely to have low/reduced BMD than girls (30.1% vs. 12.9%, P < 0.001). The rate of low/reduced BMD significantly increased with age in boys (Ptrend = 0.019), whereas decreased with age in girls (Ptrend = 0.018). We found significant interaction effect between gender and height standard deviation score (height-Z) in the association with low/reduced BMD (Pinteraction < 0.001). There was a positive association of height-Z among boys (OR = 1.30, 95%CI 1.21–1.39, P < 0.001), meanwhile low/reduced BMD was inversely associated with height-Z among girls (OR = 0.85, 95%CI 0.78–0.94, P < 0.001).

Conclusions

Our study suggested strong gender disparities in the impact of height on BMD in Chinese adolescents aged 12-14 years old, where the association between low/reduced BMD and height was positive among boys but inverse among girls. The study provides evidence on the early prevention and the risk factor identification of low/reduced BMD and childhood fractures.

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Acknowledgements

The authors thank all the adolescents who participated in the Youth Health Care Promotion Program (YHCPP).

Author information

Author notes

  1. Chengshu Yu and Shuo Wang co-first authors contributed equally to this work.

  2. Ming Zhao and Junhong Leng co-corresponding authors contributed equally to this work.

Authors and Affiliations

  1. Health and Family Planning Service Center for Women and Children in Dongli District, Xianfeng Road, Dongli District, Tianjin, 300300, China

    Chengshu Yu, Xuemei Meng, Yanmei Deng, Zhongxian Xu & Ming Zhao

  2. Tianjin Women’s and Children’s Health Center, Guizhou Road, Heping District, Tianjin, 300070, China

    Shuo Wang, Weiqin Li, Nan Li, Leishen Wang & Junhong Leng

Authors
  1. Chengshu Yu
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  2. Shuo Wang
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  3. Xuemei Meng
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  4. Weiqin Li
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  5. Yanmei Deng
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  6. Nan Li
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  7. Zhongxian Xu
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  8. Leishen Wang
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  9. Ming Zhao
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  10. Junhong Leng
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Corresponding authors

Correspondence to Ming Zhao or Junhong Leng.

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Ethics approval and consent to participate

The study was approved by the Ethics Committee of Tianjin Women’s and Children’s Health Center, and written informed consent was provided by all participants.

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Yu, C., Wang, S., Meng, X. et al. The impact of height on low/reduced bone mineral density in Chinese adolescents aged 12-14 years old: gender differences. Arch Osteoporos 14, 78 (2019). https://doi.org/10.1007/s11657-019-0606-1

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