References
McCloskey E, Kanis JA, Johansson H, Harvey N, Oden A, Cooper A, Cooper C, Francis RM, Reid DM, Marsh D, Selby P, Thompson F, Hewitt S, Compston J (2015) FRAX-based assessment and intervention thresholds—an exploration of thresholds in women aged 50 years and older in the UK. Osteoporos Int 26:2091–2099
Kanis JA, McCloskey EV, Harvey NC, Johansson H, Leslie WD (2015) Intervention thresholds and the diagnosis of osteoporosis. J Bone Miner Res 30:1747–1753
Kanis JA, Harvey NC, Johansson H, Oden A, Leslie WD, McCloskey EV (2015) FRAX and fracture prediction without bone mineral density. Climacteric. doi:10.3109/13697137.2015.1092342
Leslie WD, Lix LM, Morin SN, Johansson H, Oden A, McCloskey EV, Kanis JA (2015) Hip axis length is a FRAX- and bone density-independent risk factor for hip fracture in women. J Clin Endocrinol Metab 100:2063–2070
McCloskey EV, Oden A, Harvey NC, Leslie WD, Hans D, Johansson H, Barkmann R, Boutroy S, Brown J, Chapurlat R, Elders PJ, Fujita Y, Gluer CC, Goltzman D, Iki M, Karlsson M, Kindmark A, Kotowicz M, Kurumatani N, Kwok T, Lamy O, Leung J, Lippuner K, Ljunggren O, Lorentzon M, Mellstrom D, Merlijn T, Oei L, Ohlsson C, Pasco JA, Rivadeneira F, Rosengren B, Sornay-Rendu E, Szulc P, Tamaki J, Kanis JA (2015) A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX. J Bone Miner Res. doi:10.1002/jbmr.2734
Harvey NC, Johansson H, Oden A, Karlsson MK, Rosengren BE, Ljunggren O, Cooper C, McCloskey E, Kanis JA, Ohlsson C, Mellstrom D (2015) FRAX predicts incident falls in elderly men: findings from MrOs Sweden. Osteoporos Int. doi:10.1007/s00198-015-3295-7
Meakin LB, Price JS, Lanyon LE (2014) The contribution of experimental in vivo models to understanding the mechanisms of adaptation to mechanical loading in bone. Front Endocrinol 5:154
Sugiyama T, Meakin LB, Browne WJ, Galea GL, Price JS, Lanyon LE (2012) Bones’ adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition. J Bone Miner Res 27:1784–1793
Schulte FA, Ruffoni D, Lambers FM, Christen D, Webster DJ, Kuhn G, Muller R (2013) Local mechanical stimuli regulate bone formation and resorption in mice at the tissue level. PLoS One 8, e62172
Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, Bouxsein ML (2013) Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. J Bone Miner Res 28:875–885
Christen P, Ito K, Ellouz R, Boutroy S, Sornay-Rendu E, Chapurlat RD, van Rietbergen B (2014) Bone remodelling in humans is load-driven but not lazy. Nat Commun 5:4855
Razi H, Birkhold AI, Weinkamer R, Duda GN, Willie BM, Checa S (2015) Aging leads to a dysregulation in mechanically driven bone formation and resorption. J Bone Miner Res 30:1864–1873
Srinivasan S, Gross TS, Bain SD (2012) Bone mechanotransduction may require augmentation in order to strengthen the senescent skeleton. Ageing Res Rev 11:353–360
Meakin LB, Galea GL, Sugiyama T, Lanyon LE, Price JS (2014) Age-related impairment of bones’ adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes. J Bone Miner Res 29:1859–1871
Birkhold AI, Razi H, Duda GN, Weinkamer R, Checa S, Willie BM (2014) The influence of age on adaptive bone formation and bone resorption. Biomaterials 35:9290–9301
Holguin N, Brodt MD, Sanchez ME, Silva MJ (2014) Aging diminishes lamellar and woven bone formation induced by tibial compression in adult C57BL/6. Bone 65:83–91
Milovanovic P, Zimmermann EA, Hahn M, Djonic D, Puschel K, Djuric M, Amling M, Busse B (2013) Osteocytic canalicular networks: morphological implications for altered mechanosensitivity. ACS Nano 7:7542–7551
Marie PJ (2014) Bone cell senescence: mechanisms and perspectives. J Bone Miner Res 29:1311–1321
Saito M, Marumo K (2015) Effects of collagen crosslinking on bone material properties in health and disease. Calcif Tissue Int 97:242–261
Sugiyama T, Torio T, Sato T, Matsumoto M, Kim YT, Oda H (2015) Improvement of skeletal fragility by teriparatide in adult osteoporosis patients: a novel mechanostat-based hypothesis for bone quality. Front Endocrinol 6:6
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Sugiyama, T., Kono, Y., Sekiguchi, K. et al. Age-related fragility fracture: insights from the natural homeostatic system in the skeleton. Arch Osteoporos 10, 45 (2015). https://doi.org/10.1007/s11657-015-0251-2
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DOI: https://doi.org/10.1007/s11657-015-0251-2