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Research on Mechanisms of Chinese Medicines in Prevention and Treatment of Postoperative Adhesion

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Abstract

Postoperative adhesion (PA) is currently one of the most unpleasant complications following surgical procedures. Researchers have developed several new strategies to alleviate the formation of PA to a great extent, but so far, no single measure or treatment can meet the expectations and requirements of clinical patients needing complete PA prevention. Chinese medicine (CM) has been widely used for thousands of years based on its remarkable efficacy and indispensable advantages CM treatments are gradually being accepted by modern medicine. Therefore, this review summarizes the formating process of PA and the efficacy and action mechanism of CM treatments, including their pharmacological effects, therapeutic mechanisms and advantages in PA prevention. We aim to improve the understanding of clinicians and researchers on CM prevention in the development of PA and promote the in-depth development and industrialization process of related drugs.

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Authors and Affiliations

  1. School of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China

    Ya-li Wang, Hui-xiang Zhang & Yan-qi Chen

  2. Jingwen Library, Nanjing University of Chinese Medicine, Nanjing, 210023, China

    Li-li Yang & Wen-lin Li

  3. College of Health Economics Management, Nanjing University of Chinese Medicine, Nanjing, 210023, China

    Zheng-jun Li

  4. School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China

    Min Zhao

  5. College of Acupuncture and Massage, College of Regimen and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, 210023, China

    Yao-yao Bian

  6. Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, 999078, Macau

    Li Zeng

  7. Jiangsu Provincial Engineering Center of Traditional Chinese Medicine External Medication Researching and Industrializing, Nanjing University of Chinese Medicine, Nanjing, 210023, China

    Li Zeng

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  1. Ya-li Wang
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  9. Li Zeng
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Contributions

Wang YL wrote the original draft preparation. Zhang HX, Chen YQ, Yang LL searched literature; Li ZJ, Zhao M, and LI WL helped with revision; Bian YY and Zeng L revised the article critically. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Li Zeng.

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Conflict of Interest

The authors declare no competing financial interest.

Supported by the National Natural Science Foundation of China (Nos. 82174394, 81673982, 81704084), the Science and Technology Development Fund, Macau SAR (No. 0121/2022/A3), the Faculty Research Grants of Macau University of Science and Technology (No. FRG-22-110-FC), the Natural Science Foundation of Jiangsu Province (No. BK20201401), the Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. KYCX21_1667), Chinese Medicine Technology Development Project of Jiangsu Province (No. QN202002), the Natural Science Foundation of Nanjing University of Chinese Medicine (No. NZY81704084), and the Open Projects of the Discipline of Chinese Medicine of Nanjing University Supported by the Subject of Academic priority discipline of Jiangsu Higher Education Institutions (No. ZYX03KF63)

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Wang, Yl., Zhang, Hx., Chen, Yq. et al. Research on Mechanisms of Chinese Medicines in Prevention and Treatment of Postoperative Adhesion. Chin. J. Integr. Med. 29, 556–565 (2023). https://doi.org/10.1007/s11655-023-3735-0

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