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Evaluation on Effectiveness and Safety of Chinese Herbs in Treatment of Sub-health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  • Evidence-Based Integrative Medicine
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Abstract

Objective

To evaluate the effectiveness and safety of Chinese herbs in the treatment of sub-health systematically.

Methods

Nine databases were systematically and extensively searched to collect randomized controlled trials (RCTs) about Chinese herbs in the treatment of sub-health. The outcomes included overall effective rate, main symptoms, quality of life, etc. Literature screening, data extraction and quality assessment were conducted according to Cochrane Handbook 5.1. Meta-analysis was conducted to the included literature with Review Manager Software.

Results

Seventy-two studies involving 9,296 patients with sub-health were included with 4,908 patients in experimental groups and 4,387 patients in control groups. The overall quality of included clinical research was not high. In the aspect of improving overall effective rate, relieving main symptoms, Pittsburgh sleep quality index (PSQI) score, Athens Insomnia Scale (AIS) score, Fatigue Scale-14 (FS-14), Cornell Medical Index (CMI) score and discontinuation rate, the effects of experimental groups were better than that of control groups. According to available research reports, adverse reactions in Chinese herb groups were mainly mild gastrointestinal symptoms, which did not affect the treatment.

Conclusion

Chinese herbs have a curative effect in the treatment of sub-health. However, there are no clear criteria for diagnosis and curative effectiveness judgment globally, which would affect the accuracy of curative effect evaluation.

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Authors and Affiliations

  1. China Academy of Chinese Medical Science, Beijing, 100700, China

    Jun Zhao & Hui Zhao

  2. Beijing University of Chinese Medicine, Beijing, 100029, China

    Jun Zhao & Li-min Wang

  3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, 100700, China

    Xing Liao

  4. Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China

    Zhi-geng Li

  5. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China

    Nan-yue Wang

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  1. Jun Zhao
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  2. Xing Liao
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  3. Hui Zhao
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Correspondence to Hui Zhao.

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Supported by National Natural Science Foundation of China (No. 81403324 and 81574102)

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Evaluation on Effectiveness and Safety of Chinese Herbs in Treatment of Sub-health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Zhao, J., Liao, X., Zhao, H. et al. Evaluation on Effectiveness and Safety of Chinese Herbs in Treatment of Sub-health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Chin. J. Integr. Med. 25, 471–480 (2019). https://doi.org/10.1007/s11655-018-2982-6

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